Pyrimidine containing RSV fusion inhibitors

Autor:	Antonia A. Nikitenko, Yuri Raifeld, Boris Mitsner, Howard Newman
Rok vydání:	2005
Předmět:	Pyrimidine Stereochemistry medicine.drug_class viruses Clinical Biochemistry Pharmaceutical Science Carboxamide Antiviral Agents Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Nucleophilic substitution Animals Molecular Biology Triazine chemistry.chemical_classification Triazines Organic Chemistry virus diseases respiratory system In vitro Respiratory Syncytial Viruses Sulfonamide Pyrimidines chemistry Benzene derivatives Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:427-430
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2004.10.056
Popis:	The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d556ffc5d3906e76d85a460a73d66a0 https://doi.org/10.1016/j.bmcl.2004.10.056 Zobrazit plný text záznamu Full Text from ScienceDirect