Determination of EGFR Signaling Output by Opposing Gradients of BMP and JAK/STAT Activity
Autor: | Josée Houde, Mariana Fregoso Lomas, Scott De Vito, Laura A. Nilson, Jean-François Boisclair Lachance |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Cell Biology General Biochemistry Genetics and Molecular Biology stat 03 medical and health sciences Internal medicine medicine Animals Drosophila Proteins Epidermal growth factor receptor Receptors Invertebrate Peptide Psychological repression Transcription factor Janus Kinases JAK-STAT signaling pathway Epithelium Cell biology ErbB Receptors STAT Transcription Factors Drosophila melanogaster 030104 developmental biology medicine.anatomical_structure Endocrinology Gene Expression Regulation biology.protein Signal transduction General Agricultural and Biological Sciences Signal Transduction |
Zdroj: | Current Biology. 26:2572-2582 |
ISSN: | 0960-9822 |
Popis: | A relatively small number of signaling pathways drive a wide range of developmental decisions, but how this versatility in signaling outcome is generated is not clear. In the Drosophila follicular epithelium, localized epidermal growth factor receptor (EGFR) activation induces distinct cell fates depending on its location. Posterior follicle cells respond to EGFR activity by expressing the T-box transcription factors Midline and H15, while anterior cells respond by expressing the homeodomain transcription factor Mirror. We show that the choice between these alternative outputs of EGFR signaling is regulated by antiparallel gradients of JAK/STAT and BMP pathway activity and that mutual repression between Midline/H15 and Mirror generates a bistable switch that toggles between alternative EGFR signaling outcomes. JAK/STAT and BMP pathway input is integrated through their joint and opposing regulation of both sides of this switch. By converting this positional information into a binary decision between EGFR signaling outcomes, this regulatory network ultimately allows the same ligand-receptor pair to establish both the anterior-posterior (AP) and dorsal-ventral (DV) axes of the tissue. |
Databáze: | OpenAIRE |
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