Veiled Potential of Secretagogin in Diabetes: Correlation or Coincidence?
| Autor: | Anand Kumar Sharma, Radhika Khandelwal, Yogendra Sharma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
education.field_of_study
Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment 030209 endocrinology & metabolism Biology medicine.disease 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin-Secreting Cells Diabetes mellitus Diabetes Mellitus medicine Animals Humans Regeneration education Insulin secretion Neuroscience SECRETAGOGIN Secretagogins |
| Zdroj: | Trends in Endocrinology & Metabolism. 30:234-243 |
| ISSN: | 1043-2760 |
| DOI: | 10.1016/j.tem.2019.01.007 |
| Popis: | Secretagogin (SCGN) is a calcium sensor protein enriched in neuroendocrine cells in general and pancreatic β-cells in particular. SCGN regulates insulin secretion through several Ca2+-dependent interactions. Recent studies implicate SCGN in the β-cell physiology and extracellular insulin function, making it an intriguing candidate in diabetes research. Here, we propose a conjoining theme of diversified SCGN function in diabetes pathology. In our opinion, SCGN is an attractive therapeutic candidate ascribed by its role in β-cell maintenance and neuronal functions and in the efficacy of insulin. To scrutinize the therapeutic prospects of SCGN, we abridge putative diabetes-related properties of SCGN and put forth strategies to determine the precise role of SCGN in the pathogenesis/preclusion of diabetes. |
| Databáze: | OpenAIRE |
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