The two-way interaction between the molecules that cause vaginal malodour and lactobacilli
| Autor: | Polycronis Paul Akouris, Scarlett Puebla-Barragan, Jeremy P. Burton, Mark W. Sumarah, Britney Lamb, Charlotte van der Veer, Remco Kort, Gregor Reid, Charles Carr, Kait F. Al |
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| Přispěvatelé: | Molecular Cell Physiology, AIMMS |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Biogenic amines education Article Catalysis Microbiology law.invention Inorganic Chemistry chemistry.chemical_compound Probiotic law medicine Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Cadaverine vaginal malodour dysbiosis probiotics lactobacilli vaginal microbiota biogenic amines biology Lactobacillus crispatus Probiotics Organic Chemistry Vaginosis Bacterial General Medicine Tyramine biology.organism_classification medicine.disease Computer Science Applications Chemistry Lactobacillus Vaginal malodour chemistry Lactobacilli Vagina Putrescine Dysbiosis Female Vaginal microbiota Bacterial vaginosis Bacteria |
| Zdroj: | International journal of molecular sciences Puebla-Barragan, S, Akouris, P P, Al, K F, Carr, C, Lamb, B, Sumarah, M, van der Veer, C, Kort, R, Burton, J & Reid, G 2021, ' The two-way interaction between the molecules that cause vaginal malodour and lactobacilli : An opportunity for probiotics ', International Journal of Molecular Sciences, vol. 22, no. 22, 12279, pp. 1-12 . https://doi.org/10.3390/ijms222212279 International Journal of Molecular Sciences, 22(22):12279, 1-12. Multidisciplinary Digital Publishing Institute (MDPI) International Journal of Molecular Sciences; Volume 22; Issue 22; Pages: 12279 International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 12279, p 12279 (2021) |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms222212279 |
| Popis: | Vaginal malodour is a sign of dysbiosis. The biogenic amines (BAs) cadaverine, putrescine and tyramine are known to be causative compounds. Recent reports suggest these compounds produced by pathogens might have a role beyond causing malodour; namely inhibiting the growth of lactobacilli bacteria that are crucial in the maintenance of vaginal homeostasis. The aim of this study was to identify whether certain lactobacilli strains could reduce BAs and to evaluate how Lactobacillus species were affected by these compounds. Using LC–MS and HPLC-UV, five Lactobacillus crispatus strains were identified as being capable of significantly reducing BAs from the media under in vitro conditions. Through 16S rRNA gene sequencing of vaginal swabs exposed to Bas, cadaverine was found to reduce the relative abundance of lactobacilli. When L. crispatus was exposed to media supplemented with BAs with an HCl adjusted lower pH, its growth was enhanced, demonstrating the relevance of the maintenance of an acidic vaginal environment. If strains are to be developed for probiotic application to alleviate bacterial vaginosis and other conditions affecting large numbers of women worldwide, their ability to adapt to Bas and regulate pH should be part of the experimentation. |
| Databáze: | OpenAIRE |
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