Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials
| Autor: | Thomas F. Münte, Sandra Verena Müller, Christian Georg Stief, Wido Nager, Norbert Schlote, C. Asvestis, Sönke Johannes, Udo Jonas, Dirk Schultheiss |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Central Nervous System Male medicine.medical_specialty Sildenafil Phosphodiesterase Inhibitors Urology Audiology Piperazines Sildenafil Citrate chemistry.chemical_compound Double-Blind Method Memory Auditory attention Memory functions Medicine Humans Attention Selective attention Sulfones Evoked Potentials Young male Recognition memory Cross-Over Studies business.industry Memoria Behavioral pattern respiratory tract diseases chemistry Purines cardiovascular system business |
| Zdroj: | World journal of urology. 19(1) |
| ISSN: | 0724-4983 |
| Popis: | The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies. |
| Databáze: | OpenAIRE |
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