The Relationship Between Anxiety and Incident Agitation in Alzheimer’s Disease
| Autor: | Suzanne Reeves, Harry Costello, Kathy Y. Liu, Robert Howard, Alzheimer’s Disease Neuroimaging Initiative |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Disease Anxiety Article 03 medical and health sciences 0302 clinical medicine Neuroimaging Disease severity Alzheimer Disease Risk Factors medicine Humans Dementia Apathy Longitudinal Studies Risk factor Psychomotor Agitation Aged Aged 80 and over business.industry Incidence General Neuroscience General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology 030104 developmental biology Female Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery Clinical psychology Alzheimer's Disease Neuroimaging Initiative |
| Zdroj: | J Alzheimers Dis |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Agitation in Alzheimer’s disease (AD) has been hypothesized to be an expression of anxiety, but whether anxiety early in the course of dementia could be a risk factor for developing later agitation is unknown. Objective: We used the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database to examine the longitudinal relationship between anxiety and incident agitation in individuals with a diagnosis of AD at baseline or during follow-up. Methods: Longitudinal neuropsychiatric symptom data from AD individuals who were agitation-free at study baseline (N = 272) were analyzed using mixed effects regression models to test the longitudinal relationship between baseline and incident anxiety with incident agitation. Results: Anxiety at baseline was not associated with subsequent agitation, but there was a positive linear relationship between incident anxiety and agitation over the study duration. Baseline apathy and delusions were consistently associated with subsequent agitation and greater disease severity and illness duration also appeared to be risk factors for agitation. Conclusion: Our findings support the concept that anxiety and agitation are likely to be distinct rather than equivalent constructs in mild-moderate AD. Future longitudinal cohort studies are needed to replicate these findings and further characterize potential risk factors for agitation, such as apathy and delusions. |
| Databáze: | OpenAIRE |
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