The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn
| Autor: | Oliver J. Bosch, Luisa Demarchi, Jodi L. Pawluski |
|---|---|
| Přispěvatelé: | University of Regensburg, École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), This study was supported by the Deutsche Forschungsgemeinschaft (DFG, Neuroscience Graduate Programme 'Neurobiology of Emotion Dysfunctions' GRK2174 to OJB, BO1958/8-2 to OJB)., Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Physiology
Corticotropin-Releasing Hormone media_common.quotation_subject [SDV]Life Sciences [q-bio] Mothers 030209 endocrinology & metabolism Oxytocin Stress Biochemistry Developmental psychology Fight-or-flight response Prolonged grief disorder 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Grieving mothers medicine Neural system Animals Humans Maternal Behavior media_common Pregnancy Life events Brain CRF medicine.disease Mental health Prolonged Grief Disorder 3. Good health [SDV] Life Sciences [q-bio] Infant loss Grief Female Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Peptides Peptides, Elsevier, 2021, 143, pp.170593. ⟨10.1016/j.peptides.2021.170593⟩ Peptides, 2021, 143, pp.170593. ⟨10.1016/j.peptides.2021.170593⟩ |
| ISSN: | 0196-9781 1873-5169 |
| Popis: | No Supp info; International audience; The bond between a mother and her child is the strongest bond in nature. Consequently, the loss of a child is one of the most stressful and traumatic life events that causes Prolonged Grief Disorder in up to 94 % of bereaved parents. While both parents are affected, mothers are of higher risk to develop mental health complications; yet, very little research has been done to understand the impact of the loss of a child, stillbirth and pregnancy loss on key neurobiological systems. The emotional impact of losing a child, e.g., Prolonged Grief Disorder, is likely accompanied by dysregulations in neural systems important for mental health. Among those are the neuropeptides contributing to attachment and stress processing. In this review, we present evidence for the involvement of the brain oxytocin (OXT) and corticotropin-releasing factor (CRF) systems, which both play a role in maternal behavior and the stress response, in the neurobiology of grief in mothers from a behavioral and molecular point of view. We will draw conclusions from reviewing relevant animal and human studies. However, the paucity of research on the tragic end to an integral bond in a female’s life calls for the need and responsibility to conduct further studies on mothers experiencing the loss of a child both in the clinic and in appropriate animal models. |
| Databáze: | OpenAIRE |
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