Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile

Autor: Bruno Chao Lisot, Graziele Halmenschlager, Igor Pires Drachler, Sérgio Ricardo Pioner, Ernani Luis Rhoden, Felipe Pioner Machado, Luis Vinicius Bastos de Souza
Rok vydání: 2021
Předmět:
BS
bariatric surgery
Endocrinology
Diabetes and Metabolism
LH
luteinizing hormone
Bariatric Surgery
FT
free testosterone
BT
bioavailable testosterone
E2
estradiol
Other systems of medicine
Behavioral Neuroscience
Endocrinology
Sex hormone-binding globulin
IR
insulin resistance
T
testosterone
Weight loss
SHBG
sexual hormone-binding globulin
Testosterone
Erectile Function
Original Research
Sexual Function
biology
AMS
Aging Males’ Symptoms
MOSH
male obesity-related secondary hypogonadism
MD
mean difference
Psychiatry and Mental health
SF
sexual function
CRP
C-reactive protein
Medicine
MetS
metabolic syndrome
medicine.symptom
ADAM
Androgen Deficiency in the Aging Male
Cohort study
medicine.medical_specialty
Urology
TT
total testosterone
Dermatology
GBP
gastric bypass
IIEF
International Index of Erectile Function
Weight Loss
Androgen deficiency
medicine
ED
erectile dysfunction
PDE5
phosphodiesterase type 5
Glycemic
NO
nitric oxide
business.industry
SG
sleeve gastrectomy
Anthropometry
medicine.disease
Surgery
Reproductive Medicine
Low T Symptoms
biology.protein
FSH
follicle-stimulating hormone
HbA1c
glycated hemoglobin
SD
standard deviation
business
Sexual function
RZ201-999
Zdroj: Sexual Medicine
Sexual Medicine, Vol 9, Iss 4, Pp 100400-(2021)
ISSN: 2050-1161
Popis: Introduction Male obesity has a negative correlation with plasma testosterone (T) levels and sexual function (SF). Aim To evaluate the effect of weight loss through bariatric surgery (BS) on SF, low T symptoms, and hormonal profiles in obese men. Methods Thirty-three men who underwent BS participated in this cohort study. Before surgery, all participants underwent clinical examinations, including anthropometric, lipid, glycemic, and hormonal evaluations. SF was evaluated using the International Index of Erectile Function (IIEF) questionnaire; low T symptoms were evaluated using the Aging Males’ Symptoms (AMS) and Androgen Deficiency in the Aging Male (ADAM) questionnaires. The participants were reevaluated 6 months post-surgery. Main outcome measures Sex hormone profile, SF, and low T symptoms Results After BS, a significant increase in mean total T (201 ± 111–548 ± 190 ng/dL, P < .001), free T (5.8 ± 2.8–9.3 ± 3.4 ng/dL, P < .001), bioavailable T (110.3 ± 57.8–198.6 ± 74.3 ng/dL, P < .001), and sexual hormone-binding globulin (19.8 ± 13.7–54.6 ± 23.2 nmol/L, P < .001) levels. There was a significant decrease in estradiol (64.6 ± 27.4–29.2 ± 20.0 [pg/mL], P < .001). SF significantly improved. The total IIEF score increased 5.2 points (62.3 ± 7.4–67.5 ± 7.4, P = .004), erectile function subdomain increased 2.4 points (25.7 ± 4.1–28.1 ± 3.9, P = .011), desire subdomain increased 1.0 points (8.3 ± 1.5–9.3 ± 1.6, P = .006), and intercourse satisfaction subdomain increased 1.2 points (11.4 ± 1.9–12.6 ± 1.8, P = .012). Post-surgery, a 44% reduction (P = .001) was observed in the positive ADAM questionnaire, and improvements in all domains of the AMS questionnaire were found (P < .001). Conclusion Significant weight loss through BS improves erectile function, hormonal profile, and symptoms of T deficiency. Machado FP, Rhoden EL, Pioner SR, et al. Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile. Sex Med 2021;9:100400.
Databáze: OpenAIRE
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