The Preclinical Research Progress of Stem Cells Therapy in Parkinson’s Disease
| Autor: | Jun Zhang, Rui Huang, Jie Hu, Baoyong Yan, Ci Dong, Xuerui Yu, Jing Li, Quanhai Li, Yixin Qi, Jing Zhang, Fan Zhang, Pujuan Liu, Xianyun Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Degenerative Disorder lcsh:Medicine Review Article General Biochemistry Genetics and Molecular Biology Cell therapy 03 medical and health sciences Hypokinesia Dopamine medicine Animals Humans Dementia General Immunology and Microbiology business.industry Dopaminergic lcsh:R Brain Parkinson Disease General Medicine Stem Cell Research medicine.disease Disease Models Animal Treatment Outcome 030104 developmental biology Physical therapy Stem cell medicine.symptom business Neuroscience Stem Cell Transplantation medicine.drug |
| Zdroj: | BioMed Research International, Vol 2016 (2016) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Parkinson’s disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed. |
| Databáze: | OpenAIRE |
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