The effect of intravenous ferric carboxymaltose on cardiac reverse remodelling following cardiac resynchronization therapy—the IRON-CRT trial
| Autor: | Pieter Martens, W.H. Wilson Tang, Paul Dendale, Pieter M. Vandervoort, Liesbeth Bruckers, Petra Nijst, Lieven Herbots, Wilfried Mullens, Jeroen Dauw, Matthias Dupont |
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| Přispěvatelé: | Bruckers, Liesbeth/0000-0002-6978-3002, Martens, Pieter/0000-0002-6036-2113, Dauw, Jeroen/0000-0003-4605-3450 |
| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty medicine.medical_treatment Cardiac resynchronization therapy Heart failure 030204 cardiovascular system & hematology Contractility Ferric Compounds Ventricular Function Left law.invention Cardiac Resynchronization Therapy 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Cardiac remodelling medicine Clinical endpoint Humans 030212 general & internal medicine Maltose Ejection fraction Ventricular Remodeling business.industry Iron deficiency Stroke Volume Iron Deficiencies medicine.disease Confidence interval Treatment Outcome Blood pressure cardiovascular system Randomized controlled trials Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal. 42:4905-4914 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehab411 |
| Popis: | Aims Iron deficiency is common in heart failure with reduced ejection fraction (HFrEF) and negatively affects cardiac function and structure. The study the effect of ferric carboxymaltose (FCM) on cardiac reverse remodelling and contractile status in HFrEF. Methods and results Symptomatic HFrEF patients with iron deficiency and a persistently reduced left ventricular ejection fraction (LVEF Conclusions Treatment with FCM in HFrEF patients with iron deficiency and persistently reduced LVEF after CRT results in an improvement of cardiac function measured by LVEF, LVESV, and cardiac force–frequency relationship. |
| Databáze: | OpenAIRE |
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