Single Strand DNA Breaks in Human Lymphocytes Exposed to para-Phenylenediamine and its Derivatives
| Autor: | Chin Hui Chen, Ssu Ching Chen, Soi M. Chye, Shih Hsiung Liang, You-Cheng Hseu |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Dose-Response Relationship Drug Health Toxicology and Mutagenesis General Medicine Phenylenediamines Biology Alkaline Comet Assay Toxicology medicine.disease_cause Pollution Molecular biology Para phenylenediamine Single strand dna Comet assay Hair dyes medicine Humans Female Comet Assay DNA Breaks Single-Stranded Lymphocytes Incubation Genotoxicity Single strand |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 80:58-62 |
| ISSN: | 1432-0800 0007-4861 |
| DOI: | 10.1007/s00128-007-9316-2 |
| Popis: | Para-Phenylenediamine (PPD), the main aromatic amines used in the hair dye formation, and its four derivatives (2-chloro-p-phenylenediamine, 4-chloro-o-phenylenediamine, 2-nitro-p-phenylenediamine, and 4-nitro-o-phenylenediamine) were examined for their potential to produce single strand DNA breaks in human lymphocytes using the alkaline comet assay. Results revealed that all the tested chemicals within the range of doses from 100 microM to 500 microM showed the genotoxicity in a dose-dependent manner after the incubation of lymphocytes with these chemicals for 2 h. In this study, we first reported that PPD and its four derivatives can elicit the type of single strand breaks in human lymphocytes. |
| Databáze: | OpenAIRE |
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