Cytokines in human intraocular inflammation
| Autor: | W. A. Franks, J A Ogilvie, Anthony H. Chignell, Miles Stanford, R A Wolstencroft, Ga Limb, Dudley C. Dumonde |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Necrosis genetic structures medicine.medical_treatment Vitrectomy Aqueous Humor Uveitis Cellular and Molecular Neuroscience Ophthalmology Humans Medicine Interleukin 6 Diabetic Retinopathy biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Behcet Syndrome Retinal detachment Interleukin Glaucoma Diabetic retinopathy medicine.disease eye diseases Sensory Systems Surgery Vitreous Body Cytokine biology.protein Cytokines Interleukin-2 sense organs medicine.symptom business Interleukin-1 |
| Zdroj: | Current Eye Research. 11:187-191 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.3109/02713689208999531 |
| Popis: | The presence of interleukin 6 (IL-6), interleukin 1 (IL-1), interleukin 2 (IL-2) and tumour necrosis factor (TNF) was investigated in vitreous and aqueous aspirates from eyes undergoing vitrectomy for the treatment of different inflammatory conditions. Cadaveric vitreous from 10 normal subjects were used as controls. IL-6 was observed in 5 specimens from eyes with idiopathic uveitis (range = 26-264 pg/ml), in 2 specimens from eyes with uveitis complicated with retinal detachment (28 and 279 pg/ml, respectively), in 6 samples from eyes with diabetic retinopathy (range = 5-480 pg/ml), in one sample from an eye with phacolytic glaucoma (1190 pg/ml) and in one specimen from an eye with Behçet's disease (366 pg/ml). Although IL-1 was detected in 80% of all the samples investigated, concentrations of this cytokine greater than 3 pg/ml were only observed in 2 specimens from eyes with uveitis (5 and 20 pg/ml, respectively) and 2 samples from eyes with diabetic retinopathy (3 and 31 pg/ml, respectively). TNF was present in 3 specimens from eyes with uveitis (range = 2-24 pg/ml) and 1 sample from eyes with diabetic retinopathy (4 pg/ml), but was not detected in the eyes with phacolytic glaucoma or Behçet's disease. IL-2 (less than 0.1 U/ml) was detected in one sample from an eye with uveitis, one specimen from an eye with uveitis complicated with retinal detachment and 2 samples from eyes with diabetic retinopathy. None of the cytokines measured were detected in any of the control vitreous. The present observations suggest that cytokines, particularly IL-6 and IL-1, may act as local amplification signals in pathological processes associated with chronic eye inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|