Prescription Drug Histories among Drug Overdose Decedents in Delaware

Autor:	Daniel J. O'Connell, Jascha Wagner, Ellen A. Donnelly, Tammy L. Anderson, Guanwen Qi, Steve S. Martin
Rok vydání:	2020
Předmět:	medicine.medical_specialty Prescription Drugs Health (social science) Prescription drug 030508 substance abuse Medicine (miscellaneous) Drug overdose Heroin Fentanyl 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Medical prescription Toxicology testing Opioid epidemic business.industry Public Health Environmental and Occupational Health Delaware medicine.disease Analgesics Opioid Psychiatry and Mental health Opioid Emergency medicine Drug Overdose 0305 other medical science business medicine.drug
Zdroj:	Substance Use & Misuse. 55:1892-1899
ISSN:	1532-2491 1082-6084
DOI:	10.1080/10826084.2020.1775650
Popis:	Background: The US opioid epidemic largely featured deaths from prescribed medications during Wave 1 (1990-2010), but its progression since then has resulted more so from deaths to illegal opioids-such as heroin (Wave 2 - 2010-2013) and fentanyl (Wave 3 - 2013-present). As deaths to illegally manufactured fentanyl have increased, attention to the role of prescribed opioids may be waning. However, the shifting nature of today's opioid epidemic demands we monitor how both legal and illegal drugs are involved in overdose deaths. Objectives: The purpose of our study is to investigate the prescription drug (Rx) records of overdose death decedents to illuminate the continued role of prescribed medications in Wave 3 deaths. Methods: We matched drug overdose death data and prescription drug monitoring data to investigate the prescription drug records (i.e. types of opioids and other medications) of Delaware, USA, decedents who died from a drug overdose death between January 1, 2013, and March 31, 2015 (27 months). Results: Fentanyl decedents differed significantly from other decedents in prescribed medications, including the amount and proximity of opioid and Rx fentanyl prescriptions before death. These relationships held while controlling for demographic characteristics and contributing health conditions. Conclusions: Our findings show a continued presence of Rx opioids in overdose deaths and that those dying from fentanyl had different Rx records than those who died from other drugs. Continued monitoring of Rx drugs, improved toxicology testing and greater data access for more research should follow to inform effective interventions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8e21f01836d03633da93959c57e94 https://doi.org/10.1080/10826084.2020.1775650 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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