The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo
| Autor: | Naoshi Kubo, Tetsuji Sawada, Masaichi Ohira, Kousei Hirakawa, Takeshi Hori, Eiji Ako, Masanao Yamazaki, Yoshito Yamashita |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Esophageal Neoplasms Receptor ErbB-2 medicine.drug_class Morpholines Biology Tyrosine-kinase inhibitor Mice Growth factor receptor ErbB medicine Animals Humans Epidermal growth factor receptor Phosphorylation Protein Kinase Inhibitors Protein kinase B Cell Proliferation Mitogen-Activated Protein Kinase Kinases Mice Inbred BALB C Cell growth Cancer General Medicine Cell cycle medicine.disease Xenograft Model Antitumor Assays ErbB Receptors Oncology Carcinoma Squamous Cell Cancer research biology.protein Female Proto-Oncogene Proteins c-akt |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.17.4.887 |
| Popis: | The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptors. EGFR and other members of the EGFR family have been shown to play significant roles in human cancer cell proliferation and therefore present important molecular targets for the treatment of cancer. The purpose of this study was to examine the effect of the pan-erbB tyrosine kinase inhibitor CI-1033 against esophageal squamous cell carcinoma in vitro and in vivo. We selected 4 human esophageal squamous cell carcinoma cell lines (TT, TE2, TE6, and TE10), and determined their expression of EGFR and HER2. We examined the ability of CI-1033 to inhibit cell growth in vitro and in vivo. EGFR and HER2 were overexpressed in all 4 esophageal cancer cells. We found that CI-1033 could inhibit the growth of esophageal cancer cell lines in a dose-dependent manner with the inhibition of phosphorylation of both MAPK and AKT. The oral administration of CI-1033 exerted a significant antitumor effect on esophageal cancer tumors in athymic nude mice. Our results suggest that CI-1033 effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR and HER2 with the inhibition of phosphorylation of both MAPK and AKT. Furthermore, in vivo animal studies of CI-1033 suggest that CI-1033 holds significant clinical potential in esophageal cancer. |
| Databáze: | OpenAIRE |
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