Retinal oximetry:Metabolic imaging for diseases of the retina and brain
| Autor: | Thorunn Scheving Eliasdottir, Wouter Vehmeijer, Einar Stefánsson, Martin Hammer, Margarita G. Todorova, Anna Bryndis Einarsdottir, Olof Birna Olafsdottir, Toke Bek, Leopold Schmetterer, Thor Eysteinsson, Jakob Grauslund, Gerhard Garhöfer, Martin Sin, Ingeborg Stalmans, Sveinn Hakon Hardarson, Karel Van Keer, Evelien Vandewalle, Thomas Lee Torp, Robert Arnar Karlsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cardiac output
medicine.medical_specialty Nerve fiber layer Visual Acuity Eye Retina Retinal vein occlusion Multiple sclerosis chemistry.chemical_compound Retinal vein occlusion retinal ischemia Central retinal vein occlusion Retinal Diseases Diabetic retinopathy Ophthalmology Retinitis pigmentosa Central circulation Medicine Humans Oximetry Brain Diseases Retinal atrophy business.industry retinal ischemia Retinal dystrophy Retinal Vessels Brain Retinal Glaucoma Heart Biomarker Alzheimer's disease medicine.disease Classification Sensory Systems Vein occlusion Oxygen medicine.anatomical_structure chemistry Cerebrovascular Circulation Retinal oximetry Visual Fields business Progression of glaucoma Retinopathy |
| Zdroj: | Stefánsson, E, Olafsdottir, O B, Eliasdottir, T S, Vehmeijer, W, Einarsdottir, A B, Bek, T, Torp, T L, Grauslund, J, Eysteinsson, T, Karlsson, R A, Van Keer, K, Stalmans, I, Vandewalle, E, Todorova, M G, Hammer, M, Garhöfer, G, Schmetterer, L, Šín, M & Hardarson, S H 2019, ' Retinal oximetry : Metabolic imaging for diseases of the retina and brain ', Progress in Retinal and Eye Research, vol. 70, pp. 1-22 . https://doi.org/10.1016/j.preteyeres.2019.04.001 Stefánsson, E, Olafsdottir, O B, Eliasdottir, T S, Wehmeijer, W, Einarsdottir, A B, Bek, T, Torp, T L, Grauslund, J, Eysteinsson, T, Karlsson, R A, Van Keer, K, Stalmans, I, Vandewalle, E, Todorova, M G, Hammer, M, Garhöfer, G, Schmetterer, L, Šín, M & Hardarson, S H 2019, ' Retinal oximetry : Metabolic imaging for diseases of the retina and brain ', Progress in Retinal and Eye Research, vol. 70, pp. 1-22 . https://doi.org/10.1016/j.preteyeres.2019.04.001 Progress in Retinal and Eye Research, 70, 1-22 |
| Popis: | Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. In diabetic retinopathy, retinal venous oxygen saturation is elevated and arteriovenous difference progressively reduced in advanced stages of retinopathy compared with healthy persons. This correlates with pathophysiology of diabetic retinopathy where hypoxia stimulates VEGF production. Laser treatment and vitrectomy both improve retinal oximetry values, which correlate with clinical outcome. The oximetry biomarker may allow automatic measurement of severity of diabetic retinopathy and predict its response to treatment. Central retinal vein occlusion is characterized by retinal hypoxia, which is evident in retinal oximetry. The retinal hypoxia seen on oximetry correlates with the extent of peripheral ischemia, visual acuity and thickness of macular edema. This biomarker may help diagnose and measure severity of vein occlusion and degree of retinal ischemia. Glaucomatous retinal atrophy is associated with reduced oxygen consumption resulting in reduced arteriovenous difference and higher retinal venous saturation. The oximetry findings correlate with worse visual field, thinner nerve fiber layer and smaller optic disc rim. This provides an objective biomarker for glaucomatous damage. In retinitis pigmentosa, an association exists between advanced atrophy, worse visual field and higher retinal venous oxygen saturation, lower arteriovenous difference. This biomarker may allow measurement of severity and progression of retinitis pigmentosa and other atrophic retinal diseases. Retinal oximetry offers visible light imaging of systemic and central nervous system vessels. It senses hypoxia in cardiac and pulmonary diseases. Oximetry biomarkers have been discovered in Alzheimer's disease and multiple sclerosis and oxygen levels in the retina correspond well with brain. |
| Databáze: | OpenAIRE |
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