Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile
| Autor: | YS Chan, Alex T. L. Leong, Russell W. Chan, Ed X. Wu, Patrick P. Gao, Wing-Ho Yung, Kevin K. Tsia |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Time Factors Thalamus Optogenetics Somatosensory system Rats Sprague-Dawley Visual processing 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted Animals Brain Mapping Multidisciplinary Functional integration (neurobiology) Superior colliculus Brain Dependovirus Magnetic Resonance Imaging Rats Electrophysiology 030104 developmental biology PNAS Plus Excitatory postsynaptic potential Nerve Net Calcium-Calmodulin-Dependent Protein Kinase Type 2 Psychology Neuroscience Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Proceedings of the National Academy of Sciences. 113 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1616361113 |
| Popis: | One challenge in contemporary neuroscience is to achieve an integrated understanding of the large-scale brain-wide interactions, particularly the spatiotemporal patterns of neural activity that give rise to functions and behavior. At present, little is known about the spatiotemporal properties of long-range neuronal networks. We examined brain-wide neural activity patterns elicited by stimulating ventral posteromedial (VPM) thalamo-cortical excitatory neurons through combined optogenetic stimulation and functional MRI (fMRI). We detected robust optogenetically evoked fMRI activation bilaterally in primary visual, somatosensory, and auditory cortices at low (1 Hz) but not high frequencies (5–40 Hz). Subsequent electrophysiological recordings indicated interactions over long temporal windows across thalamo-cortical, cortico-cortical, and interhemispheric callosal projections at low frequencies. We further observed enhanced visually evoked fMRI activation during and after VPM stimulation in the superior colliculus, indicating that visual processing was subcortically modulated by low-frequency activity originating from VPM. Stimulating posteromedial complex thalamo-cortical excitatory neurons also evoked brain-wide blood-oxygenation-level–dependent activation, although with a distinct spatiotemporal profile. Our results directly demonstrate that low-frequency activity governs large-scale, brain-wide connectivity and interactions through long-range excitatory projections to coordinate the functional integration of remote brain regions. This low-frequency phenomenon contributes to the neural basis of long-range functional connectivity as measured by resting-state fMRI. |
| Databáze: | OpenAIRE |
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