Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation
| Autor: | Jianming Lee, Chung-yi Chiang, J. O'Leary, E. Covell, S. Hawkins, J. Adamus |
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| Rok vydání: | 2017 |
| Předmět: |
Retinyl propionate
Adult Male Aging medicine.medical_specialty Retinyl Esters Photoaging Pharmaceutical Science Dermatology medicine.disease_cause 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Colloid and Surface Chemistry Double-Blind Method Hyperpigmentation Drug Discovery medicine Humans Vitamin A Product base business.industry Retinol Imidazoles Middle Aged medicine.disease Nasolabial fold Skin Aging medicine.anatomical_structure chemistry Chemistry (miscellaneous) 030220 oncology & carcinogenesis Drug Therapy Combination Female Irritation Climbazole medicine.symptom Diterpenes business |
| Zdroj: | International journal of cosmetic science. 39(6) |
| ISSN: | 1468-2494 |
| Popis: | Objective To evaluate a combination of retinyl propionate and climbazole (RPC) compared to 0.1% retinol for its efficacy, tolerance and ageing appearance. Method Forty-five healthy Caucasian females, ages 40–70, with moderately photodamaged facial skin, were recruited for a 16-week randomized, double-blind, IRB-approved facial study. The efficacy of RPC treatment was compared to 0.1% retinol, in the same product base formulation, with twice daily, split-face product application. Changes in overall photodamage, fine lines and wrinkles, pigmentation and irritation were visually evaluated and measured by instrumentation. Subjective appraisal of efficacy was self-assessed from images where subjects were blinded to treatment and time point. Irritancy potential was also evaluated in a 5-day randomized, double-blind, IRB-approved patch study. Results Treatment with RPC resulted in significant (P < 0.05) improvement in ageing attributes compared to 0.1% retinol treatment, with minimal irritation. More than 50% of subjects showed improvement to deep wrinkles in the crow's feet area after 5 weeks of product application, and continued improvement to deep wrinkles was observed throughout the course of the study. Similarly, improvement was observed for the appearance of lines and wrinkles in the nasolabial fold (NLF) and for mottled hyperpigmentation. The results from subjective self-assessment confirmed in vivo clinical assessments. In a separate patch study, significantly less irritation was observed with the RPC product as compared to the 0.1% retinol control product. Conclusion RPC delivered significant skin anti-ageing benefits comparable or greater than 0.1% retinol, with minimal irritation. |
| Databáze: | OpenAIRE |
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