Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy
| Autor: | Eugène Cox, Thaddeus H. Grasela, Jill Fiedler-Kelly, Chao Chen, Marcus E. Risner, Gilda P. Womble |
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| Rok vydání: | 1999 |
| Předmět: |
Phenytoin
Adult Male Adolescent Metabolic Clearance Rate medicine.medical_treatment Population Pharmacology Lamotrigine Clinical Trials Phase II as Topic Double-Blind Method medicine Humans Pharmacology (medical) Drug Interactions Dosing education Randomized Controlled Trials as Topic Retrospective Studies education.field_of_study Epilepsy business.industry Triazines Carbamazepine Drug interaction Middle Aged Anticonvulsant Clinical Trials Phase III as Topic Concomitant Phenobarbital Anticonvulsants Drug Therapy Combination Female business Primidone medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 39(4) |
| ISSN: | 0091-2700 |
| Popis: | Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines. A total of 2,407 lamotrigine plasma concentrations from 527 patients with epilepsy were analyzed. Regression equations for oral clearance were developed as a function of body size, age (18-64 years), gender, race, and use of concomitant antiepileptic drugs. The population mean apparent oral clearance of lamotrigine in adult patients receiving one concomitant enzyme-inducing antiepileptic drug and not valproic acid was estimated to be 1 mL/min/kg. Gender and age did not affect clearance significantly. On average, clearance was reduced by 25% in non-whites and increased by 13% in patients receiving more than one concomitant enzyme-inducing antiepileptic agent. Lamotrigine did not influence the disposition ofphenytoin or carbamazepine. Dosing adjustments for lamotrigine in patients receiving concomitant enzyme-inducing antiepileptic drugs and not valproic acid should not be necessary for age, gender, or the number of concomitant t enzyme-inducing antiepileptic drugs. Lamotrigine does not influence the dosing requirements for phenytoin or carbamazepine. |
| Databáze: | OpenAIRE |
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