Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society
| Autor: | Pierre Boutouyrie, Bart Spronck, Athanase D. Protogerou, Philippe Bouchard, Marie Briet, Alain Tedgui, Ernesto L. Schiffrin, Pedro Cunha, Kaisa M. Mäki-Petäjä, Jean Philippe Empana, Rhian M. Touyz, Charalambos Vlachopoulos, Luca Zanoli, Rosa Maria Bruno |
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| Přispěvatelé: | Maki-Petaja, Kaisa [0000-0001-7312-6200], Apollo - University of Cambridge Repository, Biomedische Technologie, RS: Carim - H07 Cardiovascular System Dynamics |
| Rok vydání: | 2020 |
| Předmět: |
INDUCED ENDOTHELIAL DYSFUNCTION
Physiology 030204 cardiovascular system & hematology Arthritis Rheumatoid 0302 clinical medicine cardiovascular disease 030212 general & internal medicine SYSTEMIC-LUPUS-ERYTHEMATOSUS Pulse wave velocity biology II-INDUCED HYPERTENSION FLOW-MEDIATED DILATATION Arteries large arteries C-REACTIVE PROTEIN 3. Good health medicine.anatomical_structure arterial stiffness Rheumatoid arthritis arterial stiffness cardiovascular disease inflammation large arteries pulse wave velocity Cardiology medicine.symptom Coronavirus Infections Cardiology and Cardiovascular Medicine Artery medicine.medical_specialty ACUTE MYOCARDIAL-INFARCTION pulse wave velocity Pneumonia Viral Inflammation Article Betacoronavirus 03 medical and health sciences Vascular Stiffness Internal medicine Psoriasis Internal Medicine medicine Humans CORONARY-HEART-DISEASE Vascular Diseases Pandemics SARS-CoV-2 business.industry C-reactive protein COVID-19 NECROSIS-FACTOR-ALPHA medicine.disease Atherosclerosis Inflammatory Bowel Diseases Blood pressure PULSE-WAVE VELOCITY Heart Disease Risk Factors biology.protein Arterial stiffness T-CELLS business |
| Zdroj: | Journal of Hypertension Journal of Hypertension, 38(9), 1682-1698. LIPPINCOTT WILLIAMS & WILKINS J Hypertens |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0000000000002508 |
| Popis: | Inflammation is a physiological response to aggression of pathogenic agents aimed at eliminating the aggressor agent and promoting healing. Excessive inflammation, however, may contribute to tissue damage and an alteration of arterial structure and function. Increased arterial stiffness is a well-recognized cardiovascular risk factor independent of blood pressure levels and an intermediate endpoint for cardiovascular events. In the present review we discuss immune mediated mechanisms by which inflammation can influence arterial physiology and lead to vascular dysfunction such as atherosclerosis and arterial stiffening. We also show that acute inflammation predisposes the vasculature to arterial dysfunction and stiffening, and alteration of endothelial function and that chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and psoriasis are accompanied by profound arterial dysfunction which is proportional to the severity of inflammation. Current findings suggest that treatment of inflammation by targeted drugs leads to regression of arterial dysfunction. There is hope that these treatments will improve outcomes for patients. CONDENSED ABSTRACT: Inflammation is a physiological response to aggression of pathogenic agents aimed at eliminating the aggressor agent and promoting healing. Excessive inflammation, however, may contribute to tissue damage and an alteration of arterial structure and function. Increased arterial stiffness is a well-recognized cardiovascular risk factor independent of blood pressure levels. In the present review we discuss (i) mechanisms by which inflammation can influence arterial physiology and lead to vascular dysfunction such as atherosclerosis and arterial stiffening, (ii) clinical models of vascular inflammation, and (iii) current evidence on anti-inflammatory therapy and regression of arterial dysfunction. |
| Databáze: | OpenAIRE |
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