The values of Transgelin, Stathmin, BCOR and Cyclin-D1 expression in differentiation between Uterine Leiomyosarcoma (ULMS) and Endometrial Stromal Sarcoma (ESS); diagnostic and prognostic implications
| Autor: | Mustafa Taha Abdelfattah, Mohamed Ali Alabiad, Ahmed K. El-Taher, Ola A. Harb, Elsayed I. El-Hendawy, Basant Sh Elshafaay |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty diagnosis Transgelin lcsh:Surgery Stathmin Endometrial Stromal Sarcoma 03 medical and health sciences 0302 clinical medicine Cyclin D1 Internal medicine Uterine leiomyosarcoma lcsh:Pathology medicine Endometrial stromal sarcoma biology Uterine sarcoma business.industry lcsh:RD1-811 medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis immunohistochemistry biology.protein Immunohistochemistry prognosis Sarcoma business lcsh:RB1-214 |
| Zdroj: | Surgical and Experimental Pathology, Vol 3, Iss 1, Pp 1-16 (2020) |
| ISSN: | 2520-8454 |
| DOI: | 10.1186/s42047-020-00065-0 |
| Popis: | Background Morphologic distinction between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) alone is not straightforward and has been shown to be challenging especially with poor differentiation, so immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma. Aim We aimed to assess the diagnostic utility of Transgelin, Stathmin, BCOR and Cyclin-D1 separately and in-combinations in distinguishing ULMS from ESS, and to evaluate their prognostic value in patients with such sarcoma subtypes. Material and Methods We included 44 patients with uterine sarcoma. The diagnostic performances of Transgelin, Stathmin, BCOR and Cyclin-D1 were assessed in samples from all patients using immunohistochemistry. Results The combination of Stathmin and Transgelin expression has high sensitivity and specificity for diagnosis of LMS and differentiating it from ESS; 95.5% and associated with poor prognosis in LMS patients. The combination of BCOR and Cyclin-D1 expression has high sensitivity and specificity for diagnosis of ESS and differentiating it from LMS; 90.9% and 95.5% respectively and associated with poor prognosis in ESS patients. The combination of Stathmin and Transgelin, BCOR and CyclinD1 expression has high sensitivity and specificity for diagnosis of LMS and differentiating it from ESS; 100%. Conclusion Combination of Stathmin, Transgelin, BCOR and Cycline-D1 raised the accuracy of differentiation between ULMS and ESS to 100% and has prognostic roles in such sarcomas. |
| Databáze: | OpenAIRE |
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