Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study
| Autor: | Satsuki Miyazaki, Akihiko Yonekura, Makoto Era, Shigeki Tashiro, T. Watanabe, Masato Tomita, Shingo Ota, Shimpei Morimoto, Kazuaki Yokota, Ko Chiba, Yoshihiro Yabe, Itaru Yoda, Makoto Osaki, Masako Ito, Hiroshi Enomoto, Tomoo Tsukazaki, Narihiro Okazaki, Yusaku Isobe, Sawako Nakashima, Shuntaro Sato, Shuta Yamada |
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| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty Histology Physiology Endocrinology Diabetes and Metabolism Sequential therapy Urology 030209 endocrinology & metabolism Monthly intravenous ibandronate Bone resorption Bone remodeling 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Bone Density Teriparatide medicine Humans In patient High-resolution peripheral quantitative CT (HR-pQCT) Tibia Quantitative computed tomography Ibandronic Acid Bone mineral Bone Density Conservation Agents medicine.diagnostic_test business.industry 030104 developmental biology medicine.anatomical_structure Bone microstructure Ibandronate Osteoporosis Cortical bone business medicine.drug |
| Zdroj: | Bone. 144:115770 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2020.115770 |
| Popis: | Purpose: To investigate the effects of sequential therapy with monthly intravenous ibandronate on bone mineral density (BMD) and microstructure in patients with primary osteoporosis who received teriparatide treatment. Methods: Sixty-six patients with primary osteoporosis who had undergone teriparatide treatment for more than 12 months (mean 18.6 months) received sequential therapy with 1 mg/month intravenous ibandronate for 12 months. The patients were evaluated using dual-energy X-ray absorptiometry (DXA), quantitative ultrasound, bone turnover markers, and high-resolution peripheral quantitative computed tomography (HR-pQCT) at baseline and 6 and 12 months after beginning administration. Results: At 12 months after beginning sequential therapy,the bone resorption marker, tartrate-resistant acid phosphatase-5b, decreased by 39.5%, with 82.3% of the patients exhibiting levels within the normal limit. DXA revealed that the BMD of the lumbar spine increased by 3.2%, with 79.0% of the patients exhibiting a response, and 40.3% experiencing an increase in BMD over 5%. HR-pQCT revealed that the cortical thickness of the distal tibia was increased by 2.6%. The cortical area increased by 2.5%, and the buckling ratio (an index of cortical instability) decreased by 2.5%. Most parameters of the trabecular bone showed no significant changes. These changes in the cortical bone were observed in both the distal radius and tibia and appeared beginning 6 months after treatment initiation. Conclusions: Sequential therapy with monthly intravenous ibandronate increased the BMD and improved the cortical bone microstructure of osteoporotic patients who had undergone teriparatide treatment. Bone, 144, art.no.115770; 2020 |
| Databáze: | OpenAIRE |
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