Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development
| Autor: | Mikhail I. Shtilman, Rebeca Leu Alexa, Ariana Hudita, Paul-Octavian Stanescu, Eugenia Tanasa, Aristidis Tsatsakis, Oana Stoian, Octav Ginghina, Jana Ghitman, Ionut-Cristian Radu, Yaroslav Mezhuev, Bianca Galateanu, Catalin Zaharia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biocomposite
Biocompatibility Cell Survival Surface Properties Chemistry Pharmaceutical Cell Culture Techniques Pharmaceutical Science RM1-950 wound dressing Silver sulfadiazine Polyvinyl alcohol Chitosan chemistry.chemical_compound Dynamic light scattering medicine Humans Particle Size dermal fibroblast Cellulose Antibacterial agent Drug Carriers Wound Healing bacterial cellulose technology industry and agriculture General Medicine Bandages Silver Sulfadiazine core-shell nanoparticles Drug Liberation chemistry Chemical engineering Bacterial cellulose Anti-Infective Agents Local Nanoparticles Therapeutics. Pharmacology chitosan Biocomposite Rheology Research Article medicine.drug |
| Zdroj: | Drug Delivery, Vol 28, Iss 1, Pp 1932-1950 (2021) Drug Delivery article-version (VoR) Version of Record |
| ISSN: | 1521-0464 1071-7544 |
| DOI: | 10.1080/10717544.2021.1977423 |
| Popis: | Dressing biomaterials play a key role in wound management keeping a moisture medium and protecting against external factors. Natural and synthetic materials could be used as dressings where chitosan and bacterial cellulose is one of the most important solutions. These biopolymers have been used for wound dressing based on their non-toxic, biodegradable, and biocompatible features. In this study, biocomposites based on bacterial cellulose and chitosan membranes tailored with antimicrobial loaded poly(N-isopropylacrylamide)/polyvinyl alcohol nanoparticles were prepared. Core-shell polymeric nanoparticles, bacterial cellulose/chitosan membranes, and biocomposites were independently loaded with silver sulfadiazine, a well-known sulfonamide antibacterial agent used in the therapy of mild-to-moderate infections for sensitive organisms. The chemistry, structure, morphology, and size distribution were investigated by Fourier transformed infrared spectroscopy (FTIR-ATR), RAMAN spectroscopy, Scanning electron (SEM) and Transmission electron microscopy (TEM), and Dynamic light scattering (DLS). In vitro release behaviors of silver sulfadiazine from polymeric nanoparticles and biocomposites were investigated. The biological investigations revealed good biocompatibility of both the nanoparticles and the biocomposites in terms of human dermal fibroblasts viability and proliferation potential. Finally, the drug-loaded polymeric biomaterials showed promising characteristics, proving their high potential as an alternative support to develop a biocompatible and antibacterial wound dressing. |
| Databáze: | OpenAIRE |
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