Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS after a Lifestyle Intervention
| Autor: | Johanna Giuranna, Anke Hinney, Johannes Hebebrand, Lydia Morell-Azanza, Ana Ojeda-Rodríguez, Ma Cristina Azcona-SanJulián, Amelia Marti |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pediatric Obesity Medizin Lipocalin CEBQ medicine.disease_cause Body Mass Index 0302 clinical medicine Polymorphism (computer science) Childhood obesity Child Abdominal obesity Sanger sequencing Mutation Nutrition and Dietetics Ile251Leu eating behavior and Ile251Leu Melanocortin 4 receptor Obesity Abdominal symbols Receptor Melanocortin Type 4 Female medicine.symptom childhood obesity lcsh:Nutrition. Foods and food supply medicine.medical_specialty Adolescent 030209 endocrinology & metabolism lcsh:TX341-641 Article 03 medical and health sciences symbols.namesake Lipocalin-2 Ciencias de la Salud::Medicina preventiva [Materias Investigacion] Internal medicine medicine Humans Eating behavior Life Style business.industry Weight change Genetic Variation Feeding Behavior medicine.disease 030104 developmental biology Endocrinology childhood obesity CEBQ eating behavior and Ile251Leu Spain business Food Science |
| Zdroj: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname Nutrients, Vol 11, Iss 5, p 960 (2019) Nutrients Volume 11 Issue 5 |
| Popis: | Mutations leading to a reduced function of the melanocortin-4 receptor (MC4R) exert a major gene effect on extreme obesity. Recently it was shown that the bone derived hormone lipocalin 2 (LCN2) binds to the MC4R and activates a MC4R dependent anorexigenic pathway. We identified mutations in both genes and screened the effects of MC4R and LCN2 mutations on eating behavior and weight change after a lifestyle intervention. One hundred and twelve children (11.24 ± 2.6 years, BMI-SDS 2.91 ± 1.07) with abdominal obesity participated in a lifestyle intervention. MC4R and LCN2 coding regions were screened by Sanger sequencing. Eating behavior was assessed at baseline with the Children Eating Behavior Questionnaire (CEBQ). We detected three previously described non-synonymous MC4R variants (Glu42Lys, Thr150Ile, and Arg305Gln) and one non-synonymous polymorphism (Ile251Leu). Regarding LCN2, one known non-synonymous variant (Thr124Met) was detected. Eating behavior was described in carriers of the MC4R and LCN2 mutation and in non-carriers. MC4R and LCN2 mutations were detected in 2.42% and 0.84%, respectively, of Spanish children with abdominal obesity. A number of subjects with functional mutation variants in MC4R and LCN2 were able to achieve a reduction in BMI-SDS after a lifestyle intervention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|