Evaluation of Vitamin B12 Deficiency and Associated Factors in Patients With Systemic Sclerosis
| Autor: | Turan Turhan, Selma Karaahmetoglu, Abdulsamet Erden, Alper Sari, Levent Kilic, Muhammed Kilickaya, Sedat Kiraz, Umut Kalyoncu, Berkan Armagan, Diler Tas Kilic, Ali Akdogan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Homocysteine Cross-sectional study Nutritional Status Physical examination Single Center Cobalamin Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Internal medicine polycyclic compounds medicine Humans 030212 general & internal medicine Vitamin B12 Correlation of Data 030203 arthritis & rheumatology Scleroderma Systemic biology medicine.diagnostic_test Helicobacter pylori business.industry nutritional and metabolic diseases Vitamin B 12 Deficiency Middle Aged biology.organism_classification medicine.disease Gastrointestinal Tract Vitamin B 12 Cross-Sectional Studies chemistry Immunoglobulin G Female business |
| Zdroj: | Journal of clinical rheumatology : practical reports on rheumaticmusculoskeletal diseases. 24(5) |
| ISSN: | 1536-7355 |
| Popis: | In patients with systemic sclerosis (SSc) gastrointestinal (GI) involvement, nutritional status and medications may lead to cobalamin (Vit B12) deficiency. We aimed to determine the frequency and the potential causes of Vit B12 deficiency in SSc patients.We conducted a cross-sectional analysis of 62 SSc patients in a single center in 1 year period. Medical history and physical examination of patients were reevaluated. Data about organ involvements were obtained from hospital file records. The nutritional status of the patients was assessed with Malnutrition Universal Screening Tool (MUST). Vit B12, homocysteine (except in three patients) and Helicobacter Pylori Immunoglobulin G (H. Pylori IgG) levels were measured in all patients. Vit B12 deficiency was considered as serum Vit B12 level200 pg/mL or being on Vit B12 replacement therapy. Serum Vit B12 levels of the patients were also grouped as low (200 pg/mL), borderline (200-300 pg/mL) and normal (300 pg/mL). Plasma homocysteine levels of the patients were classified as elevated (9 μmol/L) and hyperhomocysteinemia (15 μmol/L). Mann-Whitney U and Kruskal-Wallis tests were used to compare parameters among the groups. Correlation was tested by Spearman's correlation coefficient.Forty-four (71.0%) patients were defined as Vit B12 deficient; 22 had Vit B12 level200 pg/mL (four were on Vit B12 replacement therapy) and the remaining 22 had Vit B12200 pg/mL and were already on Vit B12 replacement therapy. The percentage of the patients with hyperhomocysteinemia was significantly higher in the group with Vit B12200 pg/mL as compared to other groups (P = 0.004) but only 33.3% (7/21) of the patients with Vit B12200 pg/mL had hyperhomocysteinemia. There were no statistically significant differences between patients with and without Vit B12 deficiency regarding age, mean disease duration, MUST scores, mean hemoglobin levels, H. Pylori IgG positivity and organ involvements (P0.05 for all).Vit B12 deficiency is frequent in SSc and has multiple causes. All patients should be monitored for Vit B12 deficiency. The homocysteine levels seem unlikely to be helpful for confirmation of Vit B12 deficiency. |
| Databáze: | OpenAIRE |
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