Hypotensive Activity of the Ethanol Extract of Pavetta crassipes Leaves
Autor: | Samson Amos, Peter A. Akah, Charles Wambebe, A. O. Ogundaini, L. Binda, Nkechi M. Enwerem, Karniyus S. Gamaniel, Isa M. Hussaini |
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Rok vydání: | 2003 |
Předmět: |
Male
medicine.medical_specialty Contraction (grammar) Muscle Relaxation Mepyramine Pharmaceutical Science Blood Pressure Rubiaceae Propranolol Muscle Smooth Vascular Mice Vas Deferens Phentolamine Internal medicine medicine Animals Atrial Appendage Medicine African Traditional Aorta Pavetta Pharmacology CATS Dose-Response Relationship Drug Ethanol biology Plant Extracts Portal Vein business.industry Vas deferens General Medicine biology.organism_classification Rats Plant Leaves Atropine medicine.anatomical_structure Endocrinology Hypertension Injections Intravenous Cats Female Hypotension business Phytotherapy medicine.drug |
Zdroj: | Biological and Pharmaceutical Bulletin. 26:1674-1680 |
ISSN: | 1347-5215 0918-6158 |
Popis: | Pavetta crassipes leaf is routinely used locally in Nigeria for the management of respiratory disorders and hypertension. The hypotensive and other cardiovascular effects of Pavetta crassipes were investigated in cats and rats. The effects of the extract on rat and cat blood pressures, isolated rat atria, rat portal vein, isolated rat aorta and rat vas deferens were studied. Specific receptor antagonists (atropine, mepyramine, phentolamine, propranolol) were used to elucidate the underlying mechanism(s) involved in the cardiovascular changes induced by P. crassipes. The results revealed that the ethanolic extract of Pavetta crassipes lowered the blood pressures of cats and rats in a dose dependent manner. The extract also caused a concentration-dependent decrease in the force of contraction of the isolated rat atria and rat portal vein. The decreases in blood pressure values were attenuated in the presence of a beta-adrenoceptor antagonist, propranolol. The extract also attenuated isoprenaline-induced contraction of the rat atria. However, the extract did not affect contractions evoked by KCl, norepinephrine and 5-HT on the rat aorta. Pavetta crassipes contains biologically active substances that may be useful in the management of hypertension. |
Databáze: | OpenAIRE |
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