Palladium(II) Pincer Complexes of Functionalized Amides with S-Modified Cysteine and Homocysteine Residues: Cytotoxic Activity and Different Aspects of Their Biological Effect on Living Cells
| Autor: | Alexander S. Peregudov, Svetlana G. Churusova, Yulia V. Nelyubina, Valentina V. Brunova, Diana V. Aleksanyan, Vladimir A. Kozlov, Ekaterina Yu. Rybalkina, Olga Yu. Susova, Valentina N. Glushko, Zinaida S. Klemenkova, Evgenii I. Gutsul |
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| Rok vydání: | 2021 |
| Předmět: |
Stereochemistry
Cell Survival chemistry.chemical_element Antineoplastic Agents Apoptosis 010402 general chemistry 01 natural sciences Inorganic Chemistry Coordination Complexes Cell Line Tumor Cytotoxic T cell Humans Cysteine Physical and Theoretical Chemistry Cell Proliferation chemistry.chemical_classification Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Amides 0104 chemical sciences Pincer movement Amino acid chemistry Cell culture Drug Screening Assays Antitumor Two-dimensional nuclear magnetic resonance spectroscopy Heteronuclear single quantum coherence spectroscopy Palladium |
| Zdroj: | Inorganic chemistry. 60(13) |
| ISSN: | 1520-510X |
| Popis: | In the search for potential new metal-based antitumor agents, two series of nonclassical palladium(II) pincer complexes based on functionalized amides with S-modified cysteine and homocysteine residues have been prepared and fully characterized by 1D and 2D NMR (1H, 13C, COSY, HMQC or HSQC, 1H-13C, and 1H-15N HMBC) and IR spectroscopy and, in some cases, X-ray diffraction. Most of the resulting complexes exhibit a high level of cytotoxic activity against several human cancer cell lines, including colon (HCT116), breast (MCF7), and prostate (PC3) cancers. Some of the compounds under consideration are also efficient in both native and doxorubicin-resistant transformed breast cells HBL100, suggesting the prospects for the creation of therapeutic agents based on the related compounds that would be able to overcome drug resistance. An analysis of different aspects of their biological effects on living cells has revealed a remarkable ability of the S-modified derivatives to induce cell apoptosis and efficient cellular uptake of their fluorescein-conjugated counterpart, confirming the high anticancer potential of Pd(II) pincer complexes derived from functionalized amides with S-donor amino acid pendant arms. |
| Databáze: | OpenAIRE |
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