Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Autor:	Alan C. Cheng, Karina Romero, Jasmine Lin, Hanh Nho Nguyen, Yihong Zhou, Paul E. Hughes, Vinod F. Patel, Stephanie D. Geuns-Meyer, Philip R. Olivieri, James Bready, Annette Bak, Sean Caenepeel, Joseph L. Kim, Holly L. Deak, Alexander M. Long, Angela Coxon, Steve Bellon, Douglas A. Whittington, Victor J. Cee, Brian L. Hodous, Yan Gu, Ling Wang, Jenne Fretland, Christopher Mohr, Xin Huang
Rok vydání:	2009
Předmět:	Models Molecular Benzimidazole Pyrimidine Angiogenesis Clinical Biochemistry Administration Oral Biological Availability Pharmaceutical Science Crystallography X-Ray Biochemistry chemistry.chemical_compound Pathological Angiogenesis Drug Discovery Humans Transferase Protein Kinase Inhibitors Molecular Biology Kinase Organic Chemistry Receptor TIE-2 Small molecule Bioavailability chemistry Molecular Medicine Benzimidazoles HeLa Cells
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:424-427
ISSN:	0960-894X
Popis:	Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of Tie-2 kinase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bda588e874cbf60bd04e1f234064502 https://doi.org/10.1016/j.bmcl.2008.11.056 Zobrazit plný text záznamu Full Text from ScienceDirect