Autor: |
Alan C. Cheng, Karina Romero, Jasmine Lin, Hanh Nho Nguyen, Yihong Zhou, Paul E. Hughes, Vinod F. Patel, Stephanie D. Geuns-Meyer, Philip R. Olivieri, James Bready, Annette Bak, Sean Caenepeel, Joseph L. Kim, Holly L. Deak, Alexander M. Long, Angela Coxon, Steve Bellon, Douglas A. Whittington, Victor J. Cee, Brian L. Hodous, Yan Gu, Ling Wang, Jenne Fretland, Christopher Mohr, Xin Huang |
Rok vydání: |
2009 |
Předmět: |
|
Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 19:424-427 |
ISSN: |
0960-894X |
Popis: |
Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of Tie-2 kinase. |
Databáze: |
OpenAIRE |
Externí odkaz: |
|