Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant
| Autor: | Ai-ris Y. Collier, Catherine M. Brown, Katherine A. McMahan, Jingyou Yu, Jinyan Liu, Catherine Jacob-Dolan, Abishek Chandrashekar, Dylan Tierney, Jessica L. Ansel, Marjorie Rowe, Daniel Sellers, Kunza Ahmad, Ricardo Aguayo, Tochi Anioke, Sarah Gardner, Mazuba Siamatu, Lorraine Bermudez-Rivera, Michele R. Hacker, Lawrence C. Madoff, Dan H. Barouch |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | medRxiv article-version (status) pre article-version (number) 1 |
| ISSN: | 1946-6242 1946-6234 |
| DOI: | 10.1126/scitranslmed.abn6150 |
| Popis: | Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported frequently in vaccinated individuals with waning immunity. In particular, a cluster of over 1000 infections with the SARS-CoV-2 delta variant was identified in a predominantly fully vaccinated population in Provincetown, Massachusetts in July 2021. In this study, vaccinated individuals who tested positive for SARS-CoV-2 ( n = 16) demonstrated substantially higher serum antibody responses than vaccinated individuals who tested negative for SARS-CoV-2 ( n = 23), including 32-fold higher binding antibody titers and 31-fold higher neutralizing antibody titers against the SARS-CoV-2 delta variant. Vaccinated individuals who tested positive also showed higher mucosal antibody responses in nasal secretions and higher spike protein–specific CD8 + T cell responses in peripheral blood than did vaccinated individuals who tested negative. These data demonstrate that fully vaccinated individuals developed robust anamnestic antibody and T cell responses after infection with the SARS-CoV-2 delta variant. Moreover, these findings suggest that population immunity will likely increase over time by a combination of widespread vaccination and breakthrough infections. |
| Databáze: | OpenAIRE |
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