Linking microbiota composition with antimalarial antibody response
| Autor: | Liliana Mancio-Silva, Mathilde Gendrin, Ottavia Romoli |
|---|---|
| Přispěvatelé: | Microbiote des insectes vecteurs / Microbiota of Insect Vectors [Cayenne, Guyane française], Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors, Institut Pasteur [Paris] (IP), This work is funded by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (grant no. ANR-10-LABX-62-IBEID) and by ANR JCJC MosMi to M.G. (grant no. ANR-18-CE15-0007)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-18-CE15-0007,MosMi,Remodelage du microbiote de moustique pour étudier son impact sur la transmission du paludisme(2018) |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Plasmodium MESH: Parasitemia 2019-20 coronavirus outbreak MESH: Malaria malaria severity Spleen Parasitemia Biology digestive system 010603 evolutionary biology 01 natural sciences 03 medical and health sciences fluids and secretions parasitic diseases microbiota medicine MESH: Microbiota MESH: Animals MESH: Mice 030304 developmental biology 0303 health sciences Germinal center medicine.disease biology.organism_classification MESH: Antimalarials Virology MESH: Antibody Formation 3. Good health stomatognathic diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Infectious Diseases medicine.anatomical_structure Antibody response Parasitology Malaria Microbiota composition |
| Zdroj: | Trends in Parasitology Trends in Parasitology, 2021, 37 (10), pp.853-855. ⟨10.1016/j.pt.2021.07.007⟩ |
| ISSN: | 1471-4922 |
| DOI: | 10.1016/j.pt.2021.07.007 |
| Popis: | International audience; Microbiota composition recently arose as a factor correlating with malaria infection. Mandal et al. showed, via cecal transplant and antibacterial treatment, that the mouse microbiota modulates parasitemia by affecting spleen germinal centers where B cells are matured. They further identified correlations between microbiota composition and malaria severity in Ugandan children. |
| Databáze: | OpenAIRE |
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