The Evaluation of Central Corneal Thickness and Intraocular Pressure in Conjunction with Tear IGF-1 Levels in Patients with Acromegaly
| Autor: | Ali Okuyucu, Elif Kilic Kan, Emrah Kan |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Intraocular pressure Disease status medicine.medical_specialty Eye Diseases genetic structures Cross-sectional study 030209 endocrinology & metabolism Central corneal thickness Cornea Tonometry Ocular 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Ophthalmology Acromegaly medicine Humans In patient Insulin-like growth factor Insulin-Like Growth Factor I Intraocular Pressure business.industry Significant difference General Medicine Middle Aged medicine.disease eye diseases Tear collection Surgery Cross-Sectional Studies Tears Correlation analysis 030221 ophthalmology & optometry Female sense organs business Biomarkers |
| Zdroj: | European Journal of Ophthalmology. 27:531-534 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.5301/ejo.5000932 |
| Popis: | Purpose To compare the central corneal thickness (CCT), intraocular pressure (IOP), and tear insulin-like growth factor 1 (IGF-1) levels between patients with acromegaly and a control group and to evaluate the possible effect of tear IGF-1 and duration of the disease on CCT and IOP. Methods We included 31 patients with acromegaly (study group) and 40 age- and sex-matched controls in the study. Patients with acromegaly were divided into 2 subgroups based on disease status (active/inactive). All participants underwent complete ophthalmologic evaluation including CCT and IOP values. Basal tear samples were collected from both groups and tear IGF-1 levels were measured. The CCT, IOP, and tear IGF-1 levels were compared between groups and subgroups and the association between tear IGF-I levels and ocular parameters (CCT, IOP) and disease duration were also evaluated. Results Central corneal thickness, IOP, and tear IGF-1 levels did not show a significant difference between study and control groups. We also did not find a significant difference in terms of CCT, IOP, or tear IGF-1 levels between subgroups of patients. Correlation analysis did not show an association between the duration of disease and tear IGF-1 levels with CCT or IOP. Conclusions There was no significant difference in tear IGF-1 levels between patients with acromegaly and controls. Additionally, there was no correlation between disease duration and tear IGF-1 levels with CCT or IOP levels. This lack of association may suggest that tear IGF-1 levels might not have an effect on CCT or IOP findings in patients with acromegaly. |
| Databáze: | OpenAIRE |
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