Transient receptor potential channel superfamily: Role in lower urinary tract function
| Autor: | Takahisa Domen, Masaki Nakazawa, Masakuni Ishikawa, Tetsuya Imamura, Teruyuki Ogawa, Hitoshi Yokoyama, Takashi Nagai, Osamu Ishizuka, Tomonori Minagawa, Shiro Hiragata |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Urinary Tract Physiological Phenomena medicine.medical_specialty business.industry Urology Urinary system Urinary Bladder SUPERFAMILY Bioinformatics medicine.disease Pathophysiology Pathogenesis Transient receptor potential channel Transient Receptor Potential Channels Endocrinology Lower Urinary Tract Symptoms chemistry Lower urinary tract symptoms Internal medicine medicine Humans Ankyrin Urinary Bladder Neurogenic business Receptor |
| Zdroj: | International Journal of Urology. 22:994-999 |
| ISSN: | 0919-8172 |
| Popis: | Lower urinary tract symptoms associated with neurogenic bladder and overactive bladder syndrome are mediated in part by members of the transient receptor potential channel superfamily. The best studied member of this superfamily is the vanilloid receptor. Other transient receptor potential channels, such as the melastatin receptor and the ankyrin receptor, are also active in the pathogenesis of lower urinary tract dysfunction. However, the detailed mechanisms by which the transient receptor potential channels contribute to lower urinary tract symptoms are still not clear, and the therapeutic benefits of modulating transient receptor potential channel activity have not been proved in the clinical setting. In the present review, to better understand the pathophysiology and therapeutic potential for lower urinary tract symptoms, we summarize the presence and role of different members of the transient receptor potential channel superfamily in the lower urinary tract. |
| Databáze: | OpenAIRE |
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