Preparation and investigation of vitamin B6-derived aminopyridinol antioxidants
| Autor: | Byeong Seon Jeong, Ned A. Porter, Tae-gyu Nam, Remigiusz A. Serwa, Derek A. Pratt, Christopher L. Rector, Luca Valgimigli, Sean M. Culbertson |
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| Přispěvatelé: | R. Serwa, T. Nam, L. Valgimigli, S. Culbertson, C. L. Rector, B.-S. Jeong, D. A. Pratt, N. A. Porter. |
| Rok vydání: | 2010 |
| Předmět: |
Antioxidant
medicine.medical_treatment alpha-Tocopherol Aminopyridines Catalysis Antioxidants Lipid peroxidation chemistry.chemical_compound medicine Organic chemistry Moiety Humans Pyridoxine Hydrochloride Liposome Bicyclic molecule Molecular Structure Organic Chemistry General Chemistry Free Radical Scavengers Amino Alcohols Vitamin B 6 Membrane chemistry Amine gas treating Lipid Peroxidation Oxidation-Reduction |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 16(47) |
| ISSN: | 1521-3765 |
| Popis: | 3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, α-tocopherol. We report here high-yielding, large-scale syntheses of mono- and bicyclic aminopyridinols from pyridoxine hydrochloride (i.e., vitamin B(6)). This approach provides straightforward, scaleable access to novel, potent, molecular scaffolds whose antioxidant properties have been investigated in homogeneous solutions and in liposomal vesicles. These molecular aggregates mimic cell membranes that are the targets of oxidative damage in vivo. |
| Databáze: | OpenAIRE |
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