Genome-wide association study for the level of serum electrolytes in Italian Large White pigs
| Autor: | A.B. Samoré, Samuele Bovo, Stefania Dall'Olio, Luca Fontanesi, Giuliano Galimberti, Francesca Bertolini, Giuseppina Schiavo, Gianluca Mazzoni, Daniela Giovanna Calo, Emilio Scotti, Luca Buttazzoni |
|---|---|
| Přispěvatelé: | Bovo, S., Schiavo, G., Mazzoni, G., Dall'Olio, S., Galimberti, G., Calò, D.G., Scotti, E., Bertolini, F., Buttazzoni, L., Samorè, A.B., Fontanesi, L. |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine False discovery rate Genotype Sus scrofa SNP chemistry.chemical_element Genome-wide association study Single-nucleotide polymorphism Biology Calcium association study Polymorphism Single Nucleotide Electrolytes 03 medical and health sciences Genetics Animals Magnesium Gene Genetic Association Studies Calcium metabolism Models Genetic heavy pig animal model Phosphorus Large white General Medicine calcium magnesium 030104 developmental biology chemistry clinical–chemical blood parameter Female Animal Science and Zoology phosphoru |
| Zdroj: | Animal Genetics. 47:597-602 |
| ISSN: | 0268-9146 |
| Popis: | Summary Calcium, magnesium and phosphorus are essential electrolytes involved in a large number of biological processes. Imbalance of these minerals in blood may indicate clinically relevant conditions and are important in inferring acute or chronic pathologies in humans and animals. In this work, we carried out a genome-wide association study (GWAS) for the level of these three electrolytes in the serum of 843 performance-tested Italian Large White pigs. All pigs were genotyped with the Illumina PorcineSNP60 BeadChip, and GWAS was carried out using genome-wide efficient mixed-model association. For the level of Ca2+, eight single nucleotide polymorphisms (SNPs) were significant, considering a false discovery rate (FDR) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |