Epileptic tolerance: prior seizures protect against seizure-induced neuronal injury
| Autor: | Tim Lowry, David A. Greenberg, Roger P. Simon, Masahiro Sasahira |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Nervous system Excitotoxicity Hippocampal formation Bicuculline medicine.disease_cause Hippocampus Neuroprotection Rats Sprague-Dawley Epilepsy Seizures Heat shock protein Convulsion Animals Medicine Heat-Shock Proteins Neurons business.industry General Neuroscience medicine.disease Immunohistochemistry Rats medicine.anatomical_structure medicine.symptom business Neuroscience medicine.drug |
| Zdroj: | Neuroscience Letters. 185:95-98 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(94)11233-9 |
| Popis: | Heat shock proteins (HSPs) are induced by a variety of insults to the nervous system, including seizures, and may be neuroprotective. If this is so, prior induction of HSPs should decrease neuronal damage upon re-exposure to an injurious stimulus. To test this hypothesis in relation to seizures, bicuculline was given to rats in two sessions, separated by 1, 3, 5 or 7 days; seizure activity was recorded, and HSP-like immunoreactivity and neuronal injury (acid-fuchsin staining) were quantified in the CA3c sector of the hippocampus. Prior seizures conferred a time-dependent protective effect against hippocampal injury induced by subsequent seizures, which may represent 'epileptic tolerance', analogous to the previously described phenomenon of 'ischemic tolerance'. |
| Databáze: | OpenAIRE |
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