Serum matrix metalloproteinase‐9 is elevated in men with a history of myocardial infarction
| Autor: | Anne Kalela, Matti Höyhtyä, Jaana Renko, O. Jaakkola, H. Alho, Seppo T. Nikkari, Seppo Laine |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Clinical Biochemistry Myocardial Infarction 030204 cardiovascular system & hematology Lipoproteins LDL/immunology Logistic regression Body Mass Index chemistry.chemical_compound 0302 clinical medicine Myocardial infarction Complement C3/analysis Finland 2. Zero hunger Cholesterol HDL/blood Statistics Smoking Complement C3 General Medicine Middle Aged Lipoproteins LDL Triglycerides/blood C-Reactive Protein Cholesterol Matrix Metalloproteinase 9 HDL/blood LDL/immunology lipids (amino acids peptides and proteins) Matrix Metalloproteinase 9/blood medicine.medical_specialty Lipoproteins Cholesterol/blood Statistics Nonparametric C-Reactive Protein/analysis 03 medical and health sciences Internal medicine medicine Humans Nonparametric Triglycerides Autoantibodies Aged Triglyceride business.industry Cholesterol HDL Autoantibody medicine.disease Coronary heart disease Cross-Sectional Studies Logistic Models Endocrinology chemistry Autoantibodies/blood Myocardial Infarction/blood business Body mass index 030217 neurology & neurosurgery Lipoprotein |
| Zdroj: | Renko, J, Kalela, A, Jaakkola, O, Laine, S, Höyhtyä, M, Alho, H & Nikkari, S T 2004, ' Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction ', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 64, no. 3, pp. 255-261 . https://doi.org/10.1080/00365510410006054 |
| ISSN: | 1502-7686 0036-5513 |
| Popis: | Elevated serum inflammatory markers have been reported in coronary heart disease. Levels of serum matrix metalloproteinase‐9 (MMP‐9), C‐reactive protein (CRP), C3‐complement (C3) and autoantibodies against oxidized low‐density lipoprotein (oxLDL) in 120 male subjects with a history of myocardial infarction (MI) were compared with those in 250 age‐matched controls, both groups from a large cross‐sectional population survey, the FINRISK study. The concentrations of serum MMP‐9 and autoantibodies against oxLDL were measured by enzyme‐linked immunosorbent assay, CRP and C3 by immunonephelometry. MMP‐9, CRP and C3 concentrations were higher in the subjects with a history of MI than in the controls (p=0.037, p=0.004, and p=0.006, respectively). There was no difference between the groups in serum levels of autoantibodies against oxLDL. In other background characteristics, men in the MI group had higher body mass index (BMI) and serum triglyceride values and lower serum HDL cholesterol values compared to controls (p=0.009, p=0.001, and p |
| Databáze: | OpenAIRE |
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