The pathology of pituitary adenomas from a clinical perspective
| Autor: | Alan McGregor, Simon Aylwin, Ashley B. Grossman, Dorota Dworakowska, Márta Korbonits |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Genetic Markers
Genetic syndromes Bioinformatics Fibrous Dysplasia Polyostotic General Biochemistry Genetics and Molecular Biology Pathogenesis Proto-Oncogene Proteins Chromogranins GTP-Binding Protein alpha Subunits Gs Multiple Endocrine Neoplasia Type 1 Endocrine system Medicine Humans Clinical significance Genetic Predisposition to Disease Pituitary Neoplasms Pituitary tumorigenesis Carney Complex General Immunology and Microbiology business.industry Molecular pathology Fibrous dysplasia Cell cycle medicine.disease Cyclic AMP-Dependent Protein Kinases Neoplasm Proteins Fibroblast Growth Factors Gene Expression Regulation Neoplastic Securin business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Pituitary adenomas present with a variety of clinical endocrine manifestations and arise in a sporadic setting or rarely as part of hereditary genetic syndromes. Molecular analysis of familial pituitary adenomas has provided significant insight into pituitary tumorigenesis. Some specific genes have been identified that predispose to pituitary neoplasia, but these are rarely involved in the pathogenesis of sporadic tumors. The number of identified genes involved in pituitary tumorigenesis is progressively increasing. The possible resulting mechanisms of action involve abnormalities in signal transduction pathways, cell cycle regulators, growth factors, chromosome stability and others. Further studies are needed to evaluate the clinical significance of genetic alterations and their implications for patient prognosis, as well as to identify targets for existing and new therapeutic options. The aim of this review is to focus on the molecular pathology of pituitary adenomas from a practical perspective and discuss the possible clinical implications which may relate to particular molecular alterations. We have summarised familial syndromes related to pituitary adenomas and considered the prognostic value of selected molecular alterations in these tumors. |
| Databáze: | OpenAIRE |
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