A novel glycopeptide carrying a 3-oxazolin-5-one ring obtained by intra-molecular cyclization
| Autor: | Aldo Trani, Pietro Ferrari, Michael Kurz, Gianbattista Panzone |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
Magnetic Resonance Spectroscopy Molecular Structure Stereochemistry Nuclear magnetic resonance spectroscopy Microbial Sensitivity Tests Ring (chemistry) Gram-Positive Bacteria Combinatorial chemistry Chemical synthesis Glycopeptide Anti-Bacterial Agents chemistry.chemical_compound Aglycone chemistry Drug Discovery Gram-Negative Bacteria Acid hydrolysis Teicoplanin Antibacterial activity Antibacterial agent |
| Zdroj: | The Journal of antibiotics. 51(9) |
| ISSN: | 0021-8820 |
| Popis: | The structure of a product, isolated during the synthesis of the semisynthetic glycopeptide MDL 63,246, was elucidated on the basis of spectroscopic methods and proved to be a novel glycopeptide containing a 3-oxazolin-5-one ring between positions 36 and 38. Subjected to acid hydrolysis this compound gave the corresponding pseudo aglycone and aglycone derivatives which maintained the original oxazolinone structure. Tested for antibacterial activity, these compounds showed a moderate activity against Gram-positive and inactive against Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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