Bcl2-negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 or p53 expression
| Autor: | Junji Suzumiya, Koichi Ohshima, Masahiro Kikuchi, Riko Kawano, Qing Li, Gao-Sheng Huang, Kennosuke Karube, Morishige Takeshita, Ying Guo |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
bcl-X Protein
Follicular lymphoma Apoptosis Chromosomal translocation In situ hybridization Biology Translocation Genetic Pathology and Forensic Medicine Immunoenzyme Techniques Pathogenesis immune system diseases hemic and lymphatic diseases Gene expression Biomarkers Tumor medicine Humans Lymphoma Follicular neoplasms In Situ Hybridization Fluorescence Cell Proliferation bcl-2-Associated X Protein medicine.diagnostic_test General Medicine medicine.disease BCL6 Lymphoma DNA-Binding Proteins Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-6 Cancer research Lymph Nodes Tumor Suppressor Protein p53 biological phenomena cell phenomena and immunity Fluorescence in situ hybridization |
| Zdroj: | Pathology International. 57:148-152 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2006.02072.x |
| Popis: | Bcl2 is an important protein involved in the pathogenesis of follicular lymphoma (FL). However, approximately 10% of FL cases do not express Bcl2. The present study was designed to compare gene aberrations, prosurvival gene expression, apoptosis and proliferation rates in Bcl2-positive and -negative FL cases. Bcl2 translocation and Bcl6 translocation were detected and compared using fluorescence in situ hybridization (FISH). A tendency for Bcl6 translocation to occur was found more frequently in Bcl2-negative FL than in the Bcl2-positive cases. The expression of Bcl-X, BAX, p53, Bcl6 was analyzed by immunohistochemistry. Bcl2 family proteins Bcl-X and BAX were expressed similarly in the two FL types. In some cases of Bcl2-negative FL there was high expression of Bcl6 or p53 but no such Bcl2-positive FL cases were detected. Furthermore, there was an inverse relationship between the expression of Bcl6 and p53. These results indicate that the Bcl6 translocation occurs more frequently in Bcl2-negative FL. Furthermore, other prosurvival proteins such as p53 and Bcl6 may play an important role in the pathogenesis of Bcl2-negative FL. |
| Databáze: | OpenAIRE |
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