Activation and migration of allo-peptide specific TCR transgenic T cells in cardiac allograft rejection
| Autor: | Judith A. Kapp, Kazuhito Honjo, R. Pat Bucy, Xiao Yan Xu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Graft Rejection
T-Lymphocytes T cell Immunology Receptors Antigen T-Cell CD1 Mice Transgenic Lymphocyte Activation S Phase Mice Interleukin 21 Antigen Cell Movement MHC class I medicine Animals Transplantation Homologous Cytotoxic T cell Antigen-presenting cell Cell Proliferation biology MHC class I antigen Myocardium Cell Cycle Molecular biology Mice Inbred C57BL Kinetics medicine.anatomical_structure biology.protein Heart Transplantation Lymph Nodes Spleen |
| Zdroj: | Cellular Immunology. 230:44-55 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2004.09.001 |
| Popis: | T cells from TCR transgenic mice, expressing receptors specific for an allogeneic MHC class I peptide, were used to track T cell activation and migration in normal adoptive recipients that were subsequently transplanted with heterotopic hearts that were syngeneic except for a transgenic MHC class I antigen. T cells rapidly disappeared from the blood into the lymphoid tissues where they were activated within one day after transplantation. T cells initially formed discrete clusters in the spleen and lymph nodes. After proliferating for 2-4 days in lymphoid tissues, T cells reappeared in the blood and migrated to the heart and the intestines. The T cells underwent another round of proliferation in the heart, but not the intestines, and induced cardiac rejection uniformly on 6 day. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect