Combination of ceftaroline and daptomycin as treatment for complicated osteomyelitis
| Autor: | Marta Marin, Ana Gascón, Natalia Alzueta, Marta Castresana, María Pío, Aitziber Echeverria |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.drug_class Antibiotics Case Report medicine.disease_cause 030226 pharmacology & pharmacy Microbiology 03 medical and health sciences 0302 clinical medicine Daptomycin Staphylococcus epidermidis medicine Antimicrobial stewardship Humans 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics biology Teicoplanin business.industry Osteomyelitis biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Cephalosporins Drug Combinations Staphylococcus aureus Vancomycin Female business medicine.drug |
| Zdroj: | Eur J Hosp Pharm |
| ISSN: | 2047-9956 |
| Popis: | Osteomyelitis is an infection involving bone. Staphylococcus aureus is the pathogen most frequently implicated; less frequently involved are other gram-positive organisms, such as Staphylococcus epidermidis, and also gram-negative organisms. The antibiotic of choice for treatment of osteomyelitis caused by methicillin-resistant staphylococci (MRS) is vancomycin, although other alternatives such as daptomycin or teicoplanin are also considered. Osteomyelitis caused by MRS can be difficult to treat safely and effectively. This case report describes the successful use of daptomycin combined with ceftaroline for the treatment of osteomyelitis caused by methicillin-resistant S. epidermidis (MRSE) in a 54-year-old woman, emphasising the clinical pharmacist's role in antimicrobial stewardship programmes. This alternative combination has been studied in the treatment of methicillin-resistant S. aureus (MRSA), but it may also be useful in MRSE. |
| Databáze: | OpenAIRE |
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