Bone Marrow Features in Patients With Acute Myeloid Leukemia Treated With Novel Targeted Isocitrate Dehydrogenase 1/2 Inhibitors
| Autor: | Imran Siddiqi, Poorva Vaidya, Tarek Khedro, Ashley Hagiya, Bassam Yaghmour, George Yaghmour |
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| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Myeloid IDH1 Population Isocitrate dehydrogenase inhibitors Case Report 03 medical and health sciences 0302 clinical medicine Immunophenotyping hemic and lymphatic diseases medicine education Bone marrow microenvironment education.field_of_study Acute myeloid leukemia biology CD117 business.industry Myeloid leukemia medicine.disease medicine.anatomical_structure Basophilia Oncology 030220 oncology & carcinogenesis biology.protein Bone marrow business 030215 immunology |
| Zdroj: | World Journal of Oncology |
| ISSN: | 1920-454X 1920-4531 |
| DOI: | 10.14740/wjon1231 |
| Popis: | This case report aimed to review the bone marrow features of patients with acute myeloid leukemia (AML) treated with isocitrate dehydrogenase 1/2 (IDH1/2) inhibitors. Five patients with AML treated with an IDH1/2 inhibitor were identified and retrospectively reviewed. We described the morphologic and immunophenotypic findings in the bone marrow, as well as ancillary study results. Two patients showed a hypercellular bone marrow with morphologic and immunophenotypic differentiation of blasts. The bone marrow of one patient displayed a hypoplastic phase. Four of the five patients demonstrated unusual morphologic and/or immunophenotypic populations, including basophilia with mild alterations on the myeloid blasts, a small subset of blasts with expression of T-cell markers not seen in the original immunophenotype, a cluster of differentiation 117 (CD117)-positive progenitor population with erythroid differentiation, and another population reminiscent of erythroid differentiation. Unusual morphologic and immunophenotypic populations can be seen in the bone marrows of patients treated with IDH1/2 inhibitors in the presence or absence of definite residual disease. The significance of these populations is uncertain, but further studies could be helpful to understand the meaning of these findings. |
| Databáze: | OpenAIRE |
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