Binding of herpes simplex virus to regional areas of the rodent brain
| Autor: | Dennis J. McFarland, John Hotchin, Fredrick D. Baker |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Rodent
viruses Neurotropism Biology medicine.disease_cause Binding Competitive Hippocampus Virus Cerebellum Cricetinae biology.animal medicine Animals Simplexvirus Distribution (pharmacology) Binding site Receptor Cerebral Cortex Mesocricetus Age Factors Brain Rats Inbred Strains Trypsin Virology Molecular biology Rats Muridae Herpes simplex virus Neurology Receptors Virus Female Neurology (clinical) Brain Stem medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 56:299-310 |
| ISSN: | 0022-510X |
| Popis: | The binding of 3H-thymidine labeled herpes simplex virus to homogenates of rodent brain regions and liver was examined. The results indicated that binding sites in the brain are distributed in a non-uniform manner, the specific pattern observed depending upon the age of the animal. In addition, binding was found to be reduced by pretreatment of the labeled virus with specific antiserum or trypsin. These results suggest that the distribution of herpes simplex virus receptors is one of the factors determining neurotropism and the localization of infection within the brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|