| Autor: |
Gert Rijksen, Ernst M. H. van den Doel, P. J. M. Roholl, Gerard E.J. Staal, Cees W. M. van Veelen |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Journal of Neurosurgery. 65:345-353 |
| ISSN: |
0022-3085 |
| Popis: |
✓ Gamma-enolase (one of the three possible subunits of the dimeric enzyme enolase (EC 4.2.1.11)) has been reported as a marker for human neurons. Studies investigating the presence of γ-enolase in human gliomas have given conflicting results, but a definite finding is important for further studies of the biology of these tumors and the possible use of γ-enolase as a marker for tumors originating in nervous tissue or for neuronal damage. Using electrophoresis of tumor tissue extracts as well as immunohistochemistry the authors have demonstrated the presence of γ-enolase in human gliomas. Analysis of the γ-enolase content in the plasma of patients with brain neoplasms further revealed that, although this enzyme may be present in the tumor itself, its concentration in blood is not a reliable marker for a tumor of the human central nervous system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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