Coronary Angiography-Derived Diastolic Pressure Ratio
| Autor: | Yi Tieci, Jianping Li, Yundi Feng, Fan Yang, Bo Zheng, Yuxi Li, Yong Huo, Yanjun Gong, Long Zhang, Tao Hong, Zhao-ping Liu, Yunlong Huo |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Coronary angiography medicine.medical_specialty Histology lcsh:Biotechnology Biomedical Engineering IFR Hemodynamics Bioengineering 02 engineering and technology hemodynamics FFR 03 medical and health sciences lcsh:TP248.13-248.65 Internal medicine Multicenter trial medicine Cutoff Original Research Unstable angina business.industry Bioengineering and Biotechnology 021001 nanoscience & nanotechnology medicine.disease Coronary arteries 030104 developmental biology medicine.anatomical_structure Blood pressure Cardiology DPR Core laboratory CFD 0210 nano-technology business Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) |
| ISSN: | 2296-4185 |
| Popis: | Aims: Based on the aortic pressure waveform, a specially-designed computational fluid dynamic (CFD) method was proposed to determine coronary angiography-derived diastolic pressure ratio (caDPR) without using invasive pressure wire. The aim of the study is to retrospectively assess diagnostic performance of the caDPR in the catheterization laboratory, based on a previous multicenter trial for online assessment of coronary angiography-derived FFR (caFFR). Methods and results: Patients with diagnosis of stable or unstable angina pectoris were enrolled in six centers. Wire-derived FFR was measured in coronary arteries with 30-90% diameter stenosis. Offline caDPR was assessed in blinded fashion against wire-derived FFR at an independent core laboratory. A total of 330 patients who met the inclusion/exclusion criteria were enrolled from June 26 to December 18, 2018. Offline computed caDPR and wire-derived FFR were compared in 328 interrogated vessels. The caDPR with a cutoff value of 0.89 shows diagnostic accuracy of 87.7%, sensitivity of 89.5%, specificity of 86.8%, and AUC of 0.940 against the wire-derived FFR with a cutoff value of 0.80. Conclusions: Using wired-based FFR as the standard reference, there is good diagnostic performance of the novel-CFD-design caDPR. Hence, caDPR could enhance the hemodynamic assessment of coronary lesions. |
| Databáze: | OpenAIRE |
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