Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats
| Autor: | Xiaohui Zhang, Ning Jiang, Daixin Xie, Xiaogang Zhang, Xuemei Li, Jingxi Ma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Ischemia Dishevelled Proteins Apoptosis Pharmacology Brain Ischemia Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell polarity medicine Animals chemistry.chemical_classification Gene knockdown Chemistry General Neuroscience NF-kappa B NF-κB medicine.disease Dishevelled Rats 030104 developmental biology Reperfusion Injury Reperfusion injury 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Neuroscience letters. 722 |
| ISSN: | 1872-7972 |
| Popis: | Dishevelled-1(DVL-1) has been reported associated with the regulation of cell polarity and neuronal function. However, the effect of DVL-1 in cerebral ischemia-reperfusion injury of rats remains poorly understood. In this study, we give evidence that the level of DVL-1 is increased after a middle cerebral artery occlusion/reperfusion model (MCAO) in rats, with a peak at 12 h. On the side, knockdown of DVL-1 may relieve I/R damage and restrain apoptosis after MCAO model in rats. In the part of mechanism, DVL-1 could regulate apoptosis through NF-κB. These results suggest that DVL-1 may be a potential target in I/R injury in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect