| Autor: |
Laurie Burdette, Xiao-Hang Zhao, Guo-Lan Xing, Yin Li, Chaoyu Wang, Yu-Tang Gao, Jin Wang, William Wheeler, Ying Huang, Shengli Zhou, Haijun Yang, Teng Ma, Peter Kraft, She-Gan Gao, Chang-Wei Feng, Xiaoping Miao, Li-Sha Chen, Shu-Wei Ren, Hongbing Shen, Dongxin Lin, Zhaoming Wang, Yifeng Zhou, Woon-Puay Koh, Ilyar Sheyhidin, Zhao Xueke, Yi-Min Mao, Wei Hua Jia, Li Bei, Ji-Lin Li, Wen-Bin Yue, Wancai Yang, Xiu-Qing Peng, Maxwell P. Lee, Ya-Li Liu, Xiao Liu, Yang Ke, Liangdan Sun, Ying-Fa Zhou, Charles C. Chung, Nan Hu, Bin Liu, Xiao-Shan Feng, Margaret A. Tucker, Ti Ding, Yu Liu, Amy Hutchinson, Alisa M. Goldstein, Xiu-Min Li, En-Min Li, Kan Zhai, Yan Li, Zhi-Qing Yuan, Jing Liu, Jian-Wei Ku, Yuan Yuan, Yan-Rui Zhang, Zhihua Liu, Guang-Yan Lei, Qi-De Bao, Qimin Zhan, Wei Zheng, Wu Wei, Sa Tang, Er-Tao Guo, Qirenwang Qige, Linda M. Liao, Yu-Hua Yang, Jin-Hu Fan, Shuqing Chen, Wen-Jun Yang, Neal D. Freedman, Xi Chen, Kevin B. Jacobs, Jianhua Fu, Philip R. Taylor, Ze-Zhong Tang, Stephen J. Chanock, Kai Yu, Meredith Yeager, Zhou Fuyou, Ran Wang, Yan-Long Hu, Xiao-Ou Shu, Jeff Yuenger, Wen Tan, Feng Li, Ling Yuan, Guangfu Jin, Zhi-Chao Hou, Ji-Li Cui, Jie He, Changdong Lu, Jing-Jing Han, Zhibin Hu, Xuejun Zhang, Chunling Liu, Min Han, Yi Xin Zeng, Hong-Zhang Hao, Chen Wu, Jian-Min Yuan, Chuanhai Guo, Bao-Chi Liu, Li Sun, Xin-Min Li, Christian C. Abnet, Long-Qi Chen, Liu Qin Yang, Yan Qiao, Wei Zhang, Peng Zhang, Mitchell H. Gail, Hong-Li Lin, Lixuan Wei, Zhou Wang, Tangchun Wu, Hui Meng, Joseph F. Fraumeni, Dongyun Zhang, Guo Yuan, Carol Giffen, Zong-Min Fan, Lu-Wen Wang, Dianke Yu, Sanford M. Dawsey, Bao-Gen Ma, Xue-Min Li, Jun-Yan Hong, Jiang Chang, Xue-Ping Fan, Ai-Li Li, Yong-Bing Xiang, Mei Zhang, Fang-Heng Zhu, Qing-Peng Kong, Li-Dong Wang, Li Wang, Dong Xie, Xianbo Zuo, Xin Song, Jing-Li Ren, You-Lin Qiao, Liang Wang, Weixing Zhao, Zhonghu He, Han Xuena, Ai-Qun Wu |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Nature genetics |
| ISSN: |
1546-1718
1061-4036 |
| Popis: |
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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