Are pathologists biased by clinical information?: a blinded cross-over study of the histopathological diagnosis of mesothelial tumours versus pulmonary adenocarcinoma
| Autor: | H.W. Nielsen, Otto Braendstrup, Torsten Skov, Birgit Guldhammer Skov, A.F. Lauritzen, Fred R. Hirsch |
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| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Neoplasms Mesothelial Adenocarcinoma Diagnosis Differential Immunoenzyme Techniques Bias medicine Adenocarcinoma of the lung Humans Single-Blind Method Mesothelioma Observer Variation Cross-Over Studies business.industry Respiratory disease Reproducibility of Results medicine.disease Crossover study Oncology Immunohistochemistry Histopathology Differential diagnosis business |
| Zdroj: | Lung Cancer. 11:365-372 |
| ISSN: | 0169-5002 |
| Popis: | In a blinded cross-over design, we studied whether three pathologists were biased by clinical information when making histopathological diagnoses of adenocarcinoma of the lung and benign and malignant mesothelial tumours. Furthermore, the interobserver variation of these diagnoses was assessed. Forty-one cases of adenocarcinoma of the lung and mesothelial tumours were assessed by three pathologists in four rounds. In the first two rounds, slides stained by H&E and clinical information were available. Slides and information were matched so that a specific slide in one round was given clinical information suggesting adenocarcinoma and in the other round, the clinical information suggested mesothelial tumour. In the third and fourth rounds, a panel of immunohistochemical stains was added. The clinical information was matched in the same way as in the first and second rounds. Bias by clinical information was observed when the diagnoses were made on slides stained by H&E, while no bias could be demonstrated when immunohistochemical reactions were included. The reproducibility also improved significantly when these slides were available. |
| Databáze: | OpenAIRE |
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