Urothelial hyperplasia with calculi (papillomatosis) in the urinary bladder of a male spontaneous diabetic Torii rat
| Autor: | Koichi Yabe, Kazuhiko Mori, Noriko Sasaki, Kazuyoshi Kumagai, Kayoko Ishikawa, Kiyonori Kai, Takanori Maejima, Keiko Okado, Kyohei Yasuno |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty 040301 veterinary sciences Urinary system Lumen (anatomy) Case Report Papillomatosis urologic and male genital diseases Toxicology Pathology and Forensic Medicine law.invention the spontaneously diabetic Torii rat 0403 veterinary science Urothelial Hyperplasia 03 medical and health sciences 0302 clinical medicine law medicine Atypia Von Kossa stain urinary calculus Urinary bladder business.industry 04 agricultural and veterinary sciences medicine.disease female genital diseases and pregnancy complications urothelial hyperplasia medicine.anatomical_structure Gram staining papillomatosis 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.2019-0057 |
| Popis: | A 40-week-old male spontaneous diabetic Torii rat, an animal model of type 2 diabetes mellitus, was found to have marked urinary calculi with hematuria in the urinary bladder on necropsy. Histological findings in the urinary bladder included a papillary growth pattern with a fibrovascular stroma without atypia. Fine granular materials in the bladder lumen were positive for Von Kossa staining but negative for periodic acid-Schiff or Gram staining, indicating no apparent bacterial infection in the urinary bladder. Scanning electron microscopy revealed that the urinary calculi were magnesium ammonium phosphate crystals (struvite). On the basis of the results, the lesion was diagnosed as urothelial hyperplasia with calculi (papillomatosis). Chronic inciting stimuli by struvite crystals were considered the primary cause of the bladder findings. |
| Databáze: | OpenAIRE |
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