Antibody decay after immunisation of health-care workers with an acellular pertussis vaccine
| Autor: | C. Hülße, C. H. Wirsing von König, Martina Littmann, Marion Riffelmann |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Adult Adolescent Health Personnel Enzyme-Linked Immunosorbent Assay Pertussis toxin Young Adult Vaccines Acellular Antigen Germany Medicine Humans Longitudinal Studies Whooping cough Pertussis Vaccine biology business.industry General Medicine Middle Aged medicine.disease Virology Antibodies Bacterial Vaccination Infectious Diseases Immunization Immunoglobulin G Immunology biology.protein Pertussis vaccine Pertactin Antibody business medicine.drug |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 28(3) |
| ISSN: | 1435-4373 |
| Popis: | Antibody decay after a single dose of acellular pertussis vaccine containing 25 microg of pertussis toxin (PT), 25 microg of filamentous hemagglutin (FHA), and traces of pertactin (PRN) was monitored in health-care workers. Blood was sampled 4 weeks (n = 246), 1 year (n = 187), 2 years (n = 53), 3 years (n = 134), and 4 years (n = 37) after vaccination. IgG anti-PT, IgG anti-FHA and IgG anti-PRN were measured by ELISA. Peak median antibodies to PT, FHA, and PRN were 314, 785, and 84 EU/ml respectively. IgG anti-PT decreased to a median of 29% (76 EU/ml), 18% (64 EU/ml), 19% (58 EU/ml), and 20% (63 EU/ml) of the peak value after 1, 2, 3, and 4 years respectively. IgG anti-FHA decreased more slowly, but showed similar decay patterns. In German health-care workers antibodies to pertussis antigens decayed rapidly within the first year after vaccination, but remained stable after 2, 3, and 4 years. This observation may have implications for the timing of booster vaccinations in adults. |
| Databáze: | OpenAIRE |
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