Longitudinal elastic wave imaging using nanobomb optical coherence elastography
| Autor: | Manmohan Singh, Susobhan Das, Alexander Schill, Salavat Aglyamov, Konstantin V Sokolov, Hongqiu Zhang, Kirill V. Larin, Chih-Hao Liu, Dmitry Nevozhay |
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| Rok vydání: | 2019 |
| Předmět: |
Shear waves
Materials science medicine.diagnostic_test Laser safety business.industry Attenuation 02 engineering and technology 021001 nanoscience & nanotechnology Laser 01 natural sciences Atomic and Molecular Physics and Optics Article law.invention 010309 optics Optics law 0103 physical sciences medicine Elastography Elasticity (economics) 0210 nano-technology business Axial symmetry Excitation |
| Zdroj: | Opt Lett |
| ISSN: | 1539-4794 |
| Popis: | Wave-based optical coherence elastography (OCE) is a rapidly emerging technique for elasticity assessment of tissues having high displacement sensitivity and simple implementation. However, most current noncontact wave excitation techniques are unable to target a specific tissue site in 3D and rely on transversal scanning of the imaging beam. Here, we demonstrate that dye-loaded perfluorocarbon nanoparticles (“nanobombs”) excited by a pulsed laser can produce localized axially propagating longitudinal shear waves while adhering to the laser safety limit. A phase correction method was developed and implemented to perform sensitive nanobomb elastography using ~1.5 MHz Fourier domain mode locking laser. The nanobomb activation was also monitored by detecting photoacoustic signals. The highly localized elastic waves detected by the nanobomb OCE (nb-OCE) suggest possibility of high-resolution 3D elastographic imaging. |
| Databáze: | OpenAIRE |
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